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E-GEOD-22762 - An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia

Status
Released on 13 October 2011, last updated on 14 November 2011
Organism
Homo sapiens
Samples (195)
Arrays (3)
Protocols (7)
Description
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. However, there are no gene expression scores which are able to predict overall survival in CLL based on the expression of few genes that are better than established prognostic markers. We correlated 151 CLL microarray data sets with overall survival using Cox regression and supervised principal component analysis to derive a prognostic score. This score based on the expression levels of eight genes and was validated in an independent group of 149 CLL patients by quantitative real time PCR. The score was predictive for overall survival and time to treatment in univariate Cox regression in the validation data set (both: p<0.001) and in a multivariate analysis after adjustment for 17p and 11q deletions and the IgVH-status. The score achieved superior prognostic accuracy compared to models based on genomic aberrations and IgVH-status and may support personalized therapy. Analysis of 151 samples of peripheral blood mononuclear cells (107 HGU-133plus2; 44 HGU-133A; 44 HGU-133B) from adult patients with chronic lymphocytic leukemia (CLL)
Experiment type
transcription profiling by array 
Contacts
Anne-Laure Boulesteix, Annika Dufour, Christian Buske, Jan Braess, Karsten Spiekermann, Klaus Metzeler, Manuela Bergmann, Markus Schmidberger, Medhanie Mulaw, Michael Schmidt, Michaela Feuring-Buske, Purvi Kakadia, Silvia Thoene, Stefan Bohlander, Stephanie Schneider, Till Seiler, Tobias Herold, Ulrich Mansmann, Vindi Jurinovic, Wolfgang Hiddemann, Zlatana Pasalic
Citation
An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia. Herold T, Jurinovic V, Metzeler KH, Boulesteix AL, Bergmann M, Seiler T, Mulaw M, Thoene S, Dufour A, Pasalic Z, Schmidberger M, Schmidt M, Schneider S, Kakadia PM, Feuring-Buske M, Braess J, Spiekermann K, Mansmann U, Hiddemann W, Buske C, Bohlander SK. , PMID:21625232
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