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E-GEOD-20377 - Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells

Status
Released on 23 March 2010, last updated on 1 May 2014
Organism
Mus musculus
Samples (15)
Array (1)
Protocols (6)
Description
Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML development We generated either MLL-AF9 mediated murine leukemias that originate from committed progenitor (GMP) cells or Hoxa9/Meis1a mediated murine leukemias that originate from hematopoietic stem cells (HSC). The leukemia stem cell fraction in these two type of leukemias shared a common self-renewal pathway with normal hematopoietic stem cells. Keywords: Cell type comparison Total RNA from HSC (KLS), CMP, and GMP, and from leukemia stem cells (LGMP) was isolated and hybridized to Affymetrix expresison microarrays.
Experiment type
transcription profiling by array 
Contacts
Amit Sinha <amit.sinha@childrens.harvard.edu>, Andrei V Krivtsov, Scott A Armstrong, Yingzi Wang
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-20377.idf.txt
Sample and data relationshipE-GEOD-20377.sdrf.txt
Raw data (1)E-GEOD-20377.raw.1.zip
Processed data (1)E-GEOD-20377.processed.1.zip
Array designA-AFFY-36.adf.txt
R ExpressionSetE-GEOD-20377.eSet.r
Links