Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-19285 - Expression data of multiple sclerosis patients receiving Interferon-beta therapy

Status
Released on 19 May 2010, last updated on 12 October 2011
Organism
Homo sapiens
Samples (144)
Arrays (2)
Protocols (10)
Description
The purpose of this study was to characterize the transcriptional effects induced by intramuscular IFN-beta-1a treatment (Avonex, 30 µg once weekly) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 24 MS patients within the first four weeks of IFN-beta administration. Keywords: Multiple sclerosis, Interferon, Pharmacogenomics, Affymetrix EDTA blood samples were taken from all patients immediately before first, second and fifth IFN-beta injection. Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labelled and hybridized to Affymetrix Human Genome U133 A and B arrays to quantify the mRNA levels.
Experiment type
transcription profiling by array 
Contacts
Dirk Koczan <dirk.koczan@med.uni-rostock.de>, Michael Hecker, Robert H Goertsches, Uwe K Zettl
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Links