Dbfetch

Furin-like repeat

AccessionIPR006212; (Furin_repeat) matches 38907 proteins
FullNameFurin-like repeat
TypeRepeat
SignaturesSMART: SM00261 FU
CDD: cd00064 FU
Abstract

The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation [ , , ].

References
  1. Raz E, Schejter ED, Shilo BZ. (1991)
    Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases.
    Genetics 129: 191-201
    [PUBMED:1936959] [PUB00006268]
  2. Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X. (2013)
    Structural basis for R-spondin recognition by LGR4/5/6 receptors.
    Genes Dev. 27: 1339-44
    [PUBMED:23756652] [PUB00093566]
  3. Xu JG, Huang C, Yang Z, Jin M, Fu P, Zhang N, Luo J, Li D, Liu M, Zhou Y, Zhu Y. (2015)
    Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).
    J. Biol. Chem. 290: 2455-65
    [PUBMED:25480784] [PUB00095139]
Database linksREACTOME: R-BTA-4641263;
REACTOME: R-CEL-1227986;
REACTOME: R-CEL-1250196;
REACTOME: R-CEL-1251985;
REACTOME: R-CEL-1253288;
REACTOME: R-CEL-1257604;
REACTOME: R-CEL-177929;
REACTOME: R-CEL-179812;
REACTOME: R-CEL-180292;
REACTOME: R-CEL-180336;
REACTOME: R-CEL-182971;
REACTOME: R-CEL-1963642;
REACTOME: R-CEL-2179392;
REACTOME: R-CEL-416572;
REACTOME: R-CEL-445144;
REACTOME: R-CEL-5673001;
REACTOME: R-CEL-6785631;
REACTOME: R-CEL-6811558;
REACTOME: R-CEL-8847993;
REACTOME: R-CEL-8856825;
REACTOME: R-CEL-8856828;
REACTOME: R-CEL-8863795;
REACTOME: R-CEL-9009391;
REACTOME: R-CEL-9652282;
REACTOME: R-DME-110478;
REACTOME: R-DME-1227986;
REACTOME: R-DME-1236394;
REACTOME: R-DME-1250196;
REACTOME: R-DME-1250342;
REACTOME: R-DME-1250347;
REACTOME: R-DME-1251985;
REACTOME: R-DME-1253288;
REACTOME: R-DME-1257604;
REACTOME: R-DME-1358803;
REACTOME: R-DME-177929;
REACTOME: R-DME-179812;
REACTOME: R-DME-180292;
REACTOME: R-DME-180336;
REACTOME: R-DME-182971;
REACTOME: R-DME-1963640;
REACTOME: R-DME-1963642;
REACTOME: R-DME-212718;
REACTOME: R-DME-2179392;
REACTOME: R-DME-416572;
REACTOME: R-DME-5673001;
REACTOME: R-DME-6785631;
REACTOME: R-DME-6811558;
REACTOME: R-DME-77387;
REACTOME: R-DME-8856825;
REACTOME: R-DME-8856828;
REACTOME: R-DME-8863795;
REACTOME: R-DME-9009391;
REACTOME: R-DME-9018519;
REACTOME: R-DME-9652282;
REACTOME: R-DRE-4641263;
REACTOME: R-HSA-1181150;
REACTOME: R-HSA-1227986;
REACTOME: R-HSA-1236382;
REACTOME: R-HSA-1236394;
REACTOME: R-HSA-1250196;
REACTOME: R-HSA-1250342;
REACTOME: R-HSA-1250347;
REACTOME: R-HSA-1251932;
REACTOME: R-HSA-1251985;
REACTOME: R-HSA-1253288;
REACTOME: R-HSA-1257604;
REACTOME: R-HSA-1306955;
REACTOME: R-HSA-1358803;
REACTOME: R-HSA-1442490;
REACTOME: R-HSA-1566948;
REACTOME: R-HSA-1592389;
REACTOME: R-HSA-159782;
REACTOME: R-HSA-167060;
REACTOME: R-HSA-171286;
REACTOME: R-HSA-177929;
REACTOME: R-HSA-179812;
REACTOME: R-HSA-180292;
REACTOME: R-HSA-180336;
REACTOME: R-HSA-182971;
REACTOME: R-HSA-186797;
REACTOME: R-HSA-1912420;
REACTOME: R-HSA-1963640;
REACTOME: R-HSA-1963642;
REACTOME: R-HSA-212718;
REACTOME: R-HSA-2173789;
REACTOME: R-HSA-2173796;
REACTOME: R-HSA-2179392;
REACTOME: R-HSA-2219530;
REACTOME: R-HSA-2404192;
REACTOME: R-HSA-2428928;
REACTOME: R-HSA-2428933;
REACTOME: R-HSA-416572;
REACTOME: R-HSA-445144;
REACTOME: R-HSA-4641263;
REACTOME: R-HSA-5210891;
REACTOME: R-HSA-5637810;
REACTOME: R-HSA-5638303;
REACTOME: R-HSA-5673001;
REACTOME: R-HSA-6785631;
REACTOME: R-HSA-6809371;
REACTOME: R-HSA-6811558;
REACTOME: R-HSA-74713;
REACTOME: R-HSA-74749;
REACTOME: R-HSA-74751;
REACTOME: R-HSA-74752;
REACTOME: R-HSA-77387;
REACTOME: R-HSA-8847993;
REACTOME: R-HSA-8856825;
REACTOME: R-HSA-8856828;
REACTOME: R-HSA-8857538;
REACTOME: R-HSA-8863795;
REACTOME: R-HSA-8866910;
REACTOME: R-HSA-8939256;
REACTOME: R-HSA-8963889;
REACTOME: R-HSA-9009391;
REACTOME: R-HSA-9013507;
REACTOME: R-HSA-9018519;
REACTOME: R-HSA-9609690;
REACTOME: R-HSA-9620244;
REACTOME: R-HSA-9634285;
REACTOME: R-HSA-9634638;
REACTOME: R-HSA-9652282;
REACTOME: R-HSA-9662834;
REACTOME: R-HSA-9664565;
REACTOME: R-HSA-9665233;
REACTOME: R-HSA-9665244;
REACTOME: R-HSA-9665245;
REACTOME: R-HSA-9665246;
REACTOME: R-HSA-9665247;
REACTOME: R-HSA-9665249;
REACTOME: R-HSA-9665250;
REACTOME: R-HSA-9665251;
REACTOME: R-HSA-9665348;
REACTOME: R-HSA-9665686;
REACTOME: R-HSA-9665737;
REACTOME: R-HSA-9679191;
REACTOME: R-HSA-9694614;
REACTOME: R-HSA-9733458;
REACTOME: R-HSA-977225;
REACTOME: R-HSA-9820960;
REACTOME: R-HSA-9828806;
REACTOME: R-MMU-1227986;
REACTOME: R-MMU-1236394;
REACTOME: R-MMU-1250196;
REACTOME: R-MMU-1250342;
REACTOME: R-MMU-1250347;
REACTOME: R-MMU-1251985;
REACTOME: R-MMU-1253288;
REACTOME: R-MMU-1257604;
REACTOME: R-MMU-1306955;
REACTOME: R-MMU-1358803;
REACTOME: R-MMU-1442490;
REACTOME: R-MMU-1566948;
REACTOME: R-MMU-1592389;
REACTOME: R-MMU-159782;
REACTOME: R-MMU-167060;
REACTOME: R-MMU-177929;
REACTOME: R-MMU-179812;
REACTOME: R-MMU-180292;
REACTOME: R-MMU-180336;
REACTOME: R-MMU-182971;
REACTOME: R-MMU-186797;
REACTOME: R-MMU-1912420;
REACTOME: R-MMU-1963640;
REACTOME: R-MMU-1963642;
REACTOME: R-MMU-212718;
REACTOME: R-MMU-2173789;
REACTOME: R-MMU-2173796;
REACTOME: R-MMU-2179392;
REACTOME: R-MMU-2404192;
REACTOME: R-MMU-2428928;
REACTOME: R-MMU-2428933;
REACTOME: R-MMU-416572;
REACTOME: R-MMU-445144;
REACTOME: R-MMU-4641263;
REACTOME: R-MMU-5673001;
REACTOME: R-MMU-6785631;
REACTOME: R-MMU-6811558;
REACTOME: R-MMU-74713;
REACTOME: R-MMU-74749;
REACTOME: R-MMU-74751;
REACTOME: R-MMU-74752;
REACTOME: R-MMU-77387;
REACTOME: R-MMU-8847993;
REACTOME: R-MMU-8856825;
REACTOME: R-MMU-8856828;
REACTOME: R-MMU-8857538;
REACTOME: R-MMU-8863795;
REACTOME: R-MMU-8963889;
REACTOME: R-MMU-9009391;
REACTOME: R-MMU-9013507;
REACTOME: R-MMU-9018519;
REACTOME: R-MMU-9652282;
REACTOME: R-RNO-1227986;
REACTOME: R-RNO-1236394;
REACTOME: R-RNO-1250196;
REACTOME: R-RNO-1250342;
REACTOME: R-RNO-1250347;
REACTOME: R-RNO-1251985;
REACTOME: R-RNO-1253288;
REACTOME: R-RNO-1257604;
REACTOME: R-RNO-1306955;
REACTOME: R-RNO-1358803;
REACTOME: R-RNO-1442490;
REACTOME: R-RNO-1566948;
REACTOME: R-RNO-1592389;
REACTOME: R-RNO-159782;
REACTOME: R-RNO-167060;
REACTOME: R-RNO-186797;
REACTOME: R-RNO-1963640;
REACTOME: R-RNO-1963642;
REACTOME: R-RNO-2173789;
REACTOME: R-RNO-2173796;
REACTOME: R-RNO-2404192;
REACTOME: R-RNO-2428928;
REACTOME: R-RNO-2428933;
REACTOME: R-RNO-416572;
REACTOME: R-RNO-5673001;
REACTOME: R-RNO-6785631;
REACTOME: R-RNO-6811558;
REACTOME: R-RNO-74713;
REACTOME: R-RNO-74749;
REACTOME: R-RNO-74751;
REACTOME: R-RNO-74752;
REACTOME: R-RNO-77387;
REACTOME: R-RNO-8847993;
REACTOME: R-RNO-8863795;
REACTOME: R-RNO-8963889;
REACTOME: R-RNO-9009391;
REACTOME: R-RNO-9018519;
REACTOME: R-RNO-9652282;
REACTOME: R-XTR-4641263;
PDB: 1igr; PDB: 1ivo; PDB: 1m6b; PDB: 1mox; PDB: 1n8y; PDB: 1n8z; PDB: 1nql; PDB: 1s78; PDB: 1yy9; PDB: 2a91; PDB: 2ahx; PDB: 2hr7; PDB: 3b2u; PDB: 3b2v; PDB: 3be1; PDB: 3c09; PDB: 3i2t; PDB: 3ltf; PDB: 3ltg; PDB: 3mzw; PDB: 3n85; PDB: 3njp; PDB: 3p0y; PDB: 3p11; PDB: 3qwq; PDB: 3u2p; PDB: 3u7u; PDB: 3u9u; PDB: 3w11; PDB: 3w12; PDB: 3w13; PDB: 3wlw; PDB: 3wsq; PDB: 4bso; PDB: 4bsp; PDB: 4bsr; PDB: 4bss; PDB: 4bst; PDB: 4bsu; PDB: 4c8v; PDB: 4c8w; PDB: 4c99; PDB: 4c9a; PDB: 4c9e; PDB: 4c9r; PDB: 4c9u; PDB: 4c9v; PDB: 4cdk; PDB: 4hrn; PDB: 4kng; PDB: 4krl; PDB: 4krm; PDB: 4kro; PDB: 4krp; PDB: 4kt1; PDB: 4leo; PDB: 4li2; PDB: 4oga; PDB: 4p59; PDB: 4qxf; PDB: 4ufr; PDB: 4ufs; PDB: 4uip; PDB: 4uv7; PDB: 4xss; PDB: 4xst; PDB: 4zxb; PDB: 5cus; PDB: 5j3h; PDB: 5k33; PDB: 5kqv; PDB: 5kwg; PDB: 5my6; PDB: 5o4g; PDB: 5o4o; PDB: 5o7p; PDB: 5u8q; PDB: 5u8r; PDB: 5wb7; PDB: 5wb8; PDB: 5xwd; PDB: 6aru; PDB: 6att; PDB: 6b3s; PDB: 6bgt; PDB: 6ce7; PDB: 6ce9; PDB: 6ceb; PDB: 6hn4; PDB: 6hn5; PDB: 6j71; PDB: 6jk8; PDB: 6kbi; PDB: 6lbx; PDB: 6oge; PDB: 6pxv; PDB: 6pxw; PDB: 6pyh; PDB: 6sof; PDB: 6vep; PDB: 6veq; PDB: 6vwg; PDB: 6vwh; PDB: 6vwi; PDB: 6vwj; PDB: 7bhe; PDB: 7bhf; PDB: 7bw7; PDB: 7bw8; PDB: 7bwa; PDB: 7kd6; PDB: 7len; PDB: 7lfr; PDB: 7lfs; PDB: 7md4; PDB: 7md5; PDB: 7mn5; PDB: 7mn6; PDB: 7mn8; PDB: 7mqo; PDB: 7mqr; PDB: 7mqs; PDB: 7om4; PDB: 7pg0; PDB: 7pg2; PDB: 7pg3; PDB: 7pg4; PDB: 7qid; PDB: 7qvk; PDB: 7s0q; PDB: 7s8v; PDB: 7sl1; PDB: 7sl2; PDB: 7sl3; PDB: 7sl4; PDB: 7sl6; PDB: 7sl7; PDB: 7sth; PDB: 7sti; PDB: 7stj; PDB: 7stk; PDB: 7syd; PDB: 7sye; PDB: 7sz0; PDB: 7sz1; PDB: 7sz5; PDB: 7sz7; PDB: 7tyj; PDB: 7tyk; PDB: 7tym; PDB: 7u23; PDB: 7u6d; PDB: 7u6e; PDB: 7v3p; PDB: 7xgd; PDB: 7xlc; PDB: 7yq3; PDB: 7yq4; PDB: 7yq5; PDB: 7yq6; PDB: 7yrr; PDB: 8cls; PDB: 8dtl; PDB: 8dtm; PDB: 8eyr; PDB: 8eyx; PDB: 8eyy; PDB: 8ez0; PDB: 8ffj; PDB: 8guy; PDB: 8hgo; PDB: 8hgp; PDB: 8hgs; PDB: 8pwh; PDB: 8q6j; PDB: 8tan; PDB: 8u4b; PDB: 8u4c; PDB: 8u4e; PDB: 8u4i; PDB: 8u4j; PDB: 8u4k; PDB: 8u4l; PDB: 8ukv; PDB: 8ukw; PDB: 8ukx; PDB: 8vjb; PDB: 8vjc; PDB: 8vqd; PDB: 8vqe; PDB: 8wvu; PDB: 8x06; PDB: 8x2m; PDB: 8xfp; PDB: 8xfs; PDB: 8xft; PDB: 8xjs; PDB: 8xk1; PDB: 8xkm; PDB: 8xkr; PDB: 8xum; PDB: 8y69; PDB: 8yry; PDB: 8ysz; PDB: 8yyl; PDB: 8yys; PDB: 8yyt; PDB: 9ip7; PDB: 9ip8; PDB: 9ip9; PDB: 9ipa; PDB: 9ipb; PDB: 9ipc; PDB: 9ipd; PDB: 9ipe; PDB: 9l1s;
Taxonomy DistributionArchaea: 3
Bacteria: 19
Eukaryota: 38873
Viruses: 5
metagenomes: 7