Course at EMBL-EBI
Introduction to multi-omics data integration
With the increase in the volume of data across the whole spectrum of biology, more researchers are looking to integrate omics data of different types to inform hypotheses and biological questions. This may also include public domain data, which can provide added value to data derived through researcher’s own work and inform experimental design. This introductory course will highlight the challenges that researchers face in integrating multi-omics data sets using biological examples. The course will focus on the use of public data resources and open access tools for enabling integrated working, with an emphasis on data visualisation. Please note this course does not cover statistical approaches for data integration.
Who is this course for?
This introductory course is aimed at biologists who are embarking on multi-omics projects and computational biologists / bioinformaticians who wish to gain a better understanding of the biological challenges when working with integrated datasets. No programming or command line experience is required to attend this course. Please note this course does not cover statistical approaches for data integration.
For advanced-level training in using large-scale multi-omics data and machine learning to infer biological models you may wish to consider our course on Systems Biology: From large datasets to biological insight.
What will I learn?
Learning outcomes
After this course you should be able to:
- Discuss motivations for working in an integrated manner
- Comprehend the importance of data standards and the collection of metadata
- Identify challenges for bringing different data types together
- Use a range of bioinformatics tools to organise and visualise biological data
Course content
During this course you will learn about:
- Data standards, curation and ID mapping
- Quality control for data integration
- Analysis and visualistion: Cytoscape, InterMine
- Challenges and best practice for working in an integrated manner with genomic, transcriptomic, and proteomic data
Trainers
Ricard Argelaguet
EMBL-EBI, UK Danila Bredhkin
EMBL Heidelberg, Germany Nils Eling
EMBL-EBI, UK Girolamo Giudice
EMBL-EBI, UK David Fazekas
University of Budapest, Hungary Asier Gonzalez
EMBL-EBI, UK Francesco Iorio
Wellcome Sanger Institute, UK Andrew Jarnuczak
EMBL-EBI, UK Tamas Korcsmáros
Earlham Insititute, UK Lee Larcombe
Amphimatic, UK Rachel Lyne
University of Cambridge, UK Hanna Najgebauer
EMBL-EBI, UK Sandra Orchard
EMBL-EBI, UK Pablo Porras Millan
EMBL-EBI, UK Claire O’Donovan
EMBL-EBI, UK Yasset Perez Riverol
EMBL-EBI, UK Masa Roller
EMBL-EBI, UK Michaela Spitzer
EMBL-EBI, UK
EMBL-EBI, UK
EMBL Heidelberg, Germany
EMBL-EBI, UK
EMBL-EBI, UK
University of Budapest, Hungary
EMBL-EBI, UK
Wellcome Sanger Institute, UK
EMBL-EBI, UK
Earlham Insititute, UK
Amphimatic, UK
University of Cambridge, UK
EMBL-EBI, UK
EMBL-EBI, UK
EMBL-EBI, UK
EMBL-EBI, UK
EMBL-EBI, UK
EMBL-EBI, UK
EMBL-EBI, UK
Programme
Day 1 – Tuesday 12 February 2019 |
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09:45-10:15 | Arrival and tea/coffee | |
10:15-10:30 | Welcome and introductions | Melissa Burke |
10:30-12:00 | Multiple ways to integrate multi-omics data - case studies from studying human diseases | Tamás Korcsmáros |
12:00-13:00 | Lunch | |
13:00-14:30 | Group Activity | All |
14:30-15:30 | ID Mapping | Pablo Porras |
15:30-16:00 | Tea/coffee break | |
16:00-17:30 | Quality issues – data standards, curation, ontologies and metadata | Sandra Orchard |
17:30-18:30 | Room check-in | |
18:30 | Dinner at the Wellcome Trust |
Day 2 – Wednesday 13 February 2019 |
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08:45 | Arrival | |
09:00-10:00 | Open Targets introduction and hands on |
Michaela Spitzer Asier Gonzales |
10:00-10:30 | Tea/Coffee Break | |
10:30-11:30 | Omics Discovery Index | Yasset Perez-Riverol |
11:30-12:30 | Integrated characterization of human cancer using public omics (proteomics, transcriptomics, drug sensitivity) data | Andrew Jarnuczak |
12:30-13:30 | Lunch | |
13:30-15:00 | Open tools for data integration – hands on example with InterMine | Rachel Lyne and InterMine team members |
15:00-15:30 | Tea/Coffee Break | |
15:30-17:00 | Open tools for data integration – hands on example with InterMine - continued | Rachel Lyne and InterMine team members |
17:00-18:00 | Keynote lecture | Francesco Iorio |
18:00 | End of day | |
18:30 | Dinner at the Wellcome Trust |
Day 3 – Thursday 14 February 2019 |
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08:45 | Arrival | |
09:00-10:00 | Thoughts on the interpretation of integrated data | Lee Larcombe |
10:00-10:30 | Tea/Coffee Break | |
10:30-11:00 | CELLector | Hanna Najgebauer |
11:00-12:00 | Research-based case studies |
Masa Roller Nils Eling Girolamo Giudice |
12:00-12:45 | Lunch | |
12:45-13:30 | Poster session | All |
13:30-15:30 | Multiomics factor analysis - a general framework for unsupervised integration of multiomic data sets |
Ricard Argelaguet Danila Bredhkin |
15:30-16:00 | Tea/Coffee Break | |
16:00-17:00 | Introduction to Networks and Pathways | Pablo Porras |
17:00-18:00 | Keynote lecture | Claire O'Donovan |
18:00 | End of day | |
18:30 | Dinner at the Wellcome Trust |
Day 4 – Friday 15 February 2019 |
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08:45 | Arrival | |
09:00-10:30 | Hands-on data integration with Cytoscape | Pablo Porras & Dávid Fazekas |
10:30-11:00 | Tea/Coffee Break | |
11:00-12:30 | Hands-on data integration with Cytoscape | Pablo Porras & Dávid Fazekas |
12:30-13:30 | Lunch | |
13:30-15:00 | Hands-on data integration with Cytoscape | Pablo Porras & Dávid Fazekas |
15:00-15:30 | Course wrap-up and feedback | Melissa Burke |
15:30-16:00 | Tea/Coffee Break | |
16:00 | Bus to Cambridge Station |
Please read our page on application advice before starting your application. In order to be considered for a place on this course, you must do the following:
- Complete the online application form
- Submit a Microsoft Word (.docx) document containing three short paragraphs with a biography, work history and description of your current research interests; each paragraph should be no more than 100 words
- Provide a letter of support from a supervisor or a senior co-worker explaining why you should be selected for this course
Please submit all documents to Frank O'Donnell (frank@ebi.ac.uk) by 12:00 GMT on Friday 23 November, 2018.
Incomplete applications will not be considered.
PLEASE NOTE: All participants will be expected to produce an A2 poster for the Poster Session - Posters are to include current research interests relevant to your current work.