PDBsum entry 6ftt

Transferase

PDB id: 6ftt

Contents

Protein chains

379 a.a.

207 a.a.

Ligands

PRP ×4

Metals

_CL ×12

_MG ×4

Waters ×532

PDB id:

6ftt

Name:

Transferase

Title:

Atp phosphoribosyltransferase (hiszg atpprt) from psychrobacter arcticus in complex with prpp

Structure:

Atp phosphoribosyltransferase regulatory subunit. Chain: a, c, b, d. Engineered: yes. Other_details: missing sections are due to flexible regions not visible in the electron density maps.. Atp phosphoribosyltransferase. Chain: e, h, g, f. Synonym: atp-prtase. Engineered: yes.

Source:

Psychrobacter arcticus 273-4. Organism_taxid: 259536. Gene: hisz, psyc_0676. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: hisg, psyc_1903. Expression_system_variant: c43.

Resolution:

2.29Å R-factor: 0.195 R-free: 0.238

Authors:

M.S.Alphey,Y.Ge,G.Fisher,C.M.Czekster,J.H.Naismith,R.G.Da Silva

Key ref:

M.S.Alphey et al. Catalytic and anticatalytic snapshots of a short-Form phosphoribosyltransferase. Acs catalysis, .

Date:

23-Feb-18 Release date: 24-Oct-18

Protein chains

Q4FTX3  (HISZ_PSYA2) -  ATP phosphoribosyltransferase regulatory subunit from Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)

Seq: 387 a.a.

Struc: 379 a.a.

Protein chains

Q4FQF7  (HIS1_PSYA2) -  ATP phosphoribosyltransferase from Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)

Seq: 231 a.a.

Struc: 207 a.a.

Enzyme reactions

• Enzyme class 2: Chains A, C, B, D: E.C.?
• Enzyme class 3: Chains E, H, G, F: E.C.2.4.2.17 - Atp phosphoribosyltransferase.

Pathway:

• Reaction: 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate (Bound ligand (Het Group name = PRP) corresponds exactly) + ATP

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site