PDBsum entry 6nmb

Hydrolase

PDB id: 6nmb

Contents

Protein chains

251 a.a.

Ligands

NO3 ×4

AMH ×4

Waters ×302

PDB id:

6nmb

Name:

Hydrolase

Title:

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Structure:

Urokinase-type plasminogen activator. Chain: a, b, c, d. Fragment: unp residues 164-431. Synonym: upa. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Expression_system_atcc_number: crl-1573. Expression_system_tissue: embryonic kidney.

Resolution:

2.30Å R-factor: 0.223 R-free: 0.271

Authors:

R.H.P.Law,G.Wu

Key ref:

G.Wu et al. (2019). Tranexamic acid is an active site inhibitor of urokinase plasminogen activator. Blood Adv, 3, 729-733. PubMed id: 30814058 DOI: 10.1182/bloodadvances.2018025429

Date:

10-Jan-19 Release date: 06-Mar-19

Protein chains

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 251 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

DOI no: 10.1182/bloodadvances.2018025429

Blood Adv 3:729-733 (2019)

PubMed id: 30814058

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.

G.Wu, B.A.Mazzitelli, A.J.Quek, M.J.Veldman, P.J.Conroy, T.T.Caradoc-Davies, L.M.Ooms, K.L.Tuck, J.G.Schoenecker, J.C.Whisstock, R.H.P.Law.

ABSTRACT

No abstract given.