PDBsum entry 6b1o

Hydrolase/hydrolase inhibitor

PDB id: 6b1o

Contents

Protein chains

728 a.a.

Ligands

NAG-NAG ×9

NAG ×3

C8S ×2

Waters ×1537

PDB id:

6b1o

Name:

Hydrolase/hydrolase inhibitor

Title:

The structure of dpp4 in complex with vildagliptin analog

Structure:

Dipeptidyl peptidase 4. Chain: a, b. Synonym: adabp,adenosine deaminase complexing protein 2,adcp-2, dipeptidyl peptidase iv,dpp iv,t-cell activation antigen cd26,tp103. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.91Å R-factor: 0.173 R-free: 0.202

Authors:

G.Scapin

Date:

18-Sep-17 Release date: 27-Sep-17

Protein chains

P27487  (DPP4_HUMAN) -  Dipeptidyl peptidase 4 from Homo sapiens

Seq: 766 a.a.

Struc: 728 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.14.5 - dipeptidyl-peptidase Iv.
• Reaction: Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc, from a polypeptide, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.