_EC 3.4.14.5 Dipeptidyl-peptidase Iv. 106 PDB entries  
EC 3.-.-.- Hydrolases. [21,295 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,892 PDB entries]
EC 3.4.14.- Dipeptidyl-peptidases and tripeptidyl-peptidases. [132 PDB entries]
EC 3.4.14.5 Dipeptidyl-peptidase Iv. [106 PDB entries]    
1j2e

Reaction: Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Other name(s): Dipeptidyl aminopeptidase Iv. Dpp iv. Gly-Pro naphthylamidase. Post-proline dipeptidyl aminopeptidase Iv. Xaa-Pro-dipeptidylaminopeptidase.
Comments: A membrane-bound serine-type peptidase in mammals. Ec 3.4.14.11 catalyzes a similar reaction. Belongs to peptidase family S9B.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 106 PDB entries in enzyme class E.C.3.4.14.5

  PDB code Protein
1j2e
Crystal structure of human dipeptidyl peptidase iv
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chains: A, B (729 residues) CATH domains: 2.140.10.30 3.40.50.1820
1n1m
Human dipeptidyl peptidase iv/cd26 in complex with an inhibi
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: hi5.
Chains: A, B (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
1nu6
Crystal structure of human dipeptidyl peptidase iv (dpp-iv)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
1nu8
Crystal structure of human dipeptidyl peptidase iv (dpp-iv) with diprotin a (ili)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: this sequence occurs peptide synthesis
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
1orv
Crystal structure of porcine dipeptidyl peptidase iv (cd26)
Source: Sus scrofa. Pig. Organism_taxid: 9823. Other_details: kidney
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
1orw
Crystal structure of porcine dipeptidyl peptidase iv (cd26) with a peptidomimetic inhibitor
Source: Sus scrofa. Pig. Organism_taxid: 9823. Other_details: kidney
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
1pfq
Crystal structure of human apo dipeptidyl peptidase iv / cd2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4 or adcp2 or cd26. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
1r9m
Crystal structure of human dipeptidyl peptidase iv at 2.1 an resolution.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B, C, D (727 residues) CATH domains: 2.140.10.30 3.40.50.1820
1r9n
Crystal structure of human dipeptidyl peptidase iv in comple decapeptide (tnpy) at 2.3 ang. Resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: sequence is the same as in the natural sourc
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
1rwq
Human dipeptidyl peptidase iv in complex with 5-aminomethyl- dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylami
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
1tk3
Crystal structure of human apo dipeptidyl peptidase iv/cd26
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high5.
Chains: A, B (726 residues) CATH domains: 2.140.10.30 3.40.50.1820
1tkr
Human dipeptidyl peptidase iv/cd26 inhibited with diisopropy fluorophosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high5.
Chains: A, B (726 residues) CATH domains: 2.140.10.30 3.40.50.1820
1to7
Human dipeptidyl peptidase iv/cd26 mutant y547f
Source: Homo sapiens. Human. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_cell_line: high5.
Chains: A, B (726 residues) CATH domains: 2.140.10.30 3.40.50.1820
1u8e
Human dipeptidyl peptidase iv/cd26 mutant y547f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (726 residues) CATH domains: 2.140.10.30 3.40.50.1820
1w1i
Crystal structure of dipeptidyl peptidase iv (dppiv or cd26) in complex with adenosine deaminase
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Bos taurus. Bovine. Organism_taxid: 9913.
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
1wcy
Crystal structure of human dipeptidyl peptidase iv (dppiv) c with diprotin a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Synthetic: yes. Other_details: the tripeptide was chemically synthesized
Chains: A, B (729 residues) CATH domains: 2.140.10.30 3.40.50.1820
1x70
Human dipeptidyl peptidase iv in complex with a beta amino a inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: hi5.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
1z68
Crystal structure of human fibroblast activation protein alp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (719 residues) CATH domains: 2.140.10.30 3.40.50.1820
2aj8
Porcine dipeptidyl peptidase iv (cd26) in complex with 7-ben dimethyl-8-piperazin-1-yl-3,7-dihydro-purine-2,6-dione (bdp
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2ajb
Porcine dipeptidyl peptidase iv (cd26) in complex with the t tert-butyl-gly-l-pro-l-ile (tbu-gpi)
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2ajc
Porcine dipeptidyl peptidase iv (cd26) in complex with 4-(2- aminoethyl)-benzene sulphonyl fluoride (aebsf)
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2ajd
Porcine dipeptidyl peptidase iv (cd26) in complex with l-pro pro (boropro)
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2ajl
X-ray structure of novel biaryl-based dipeptidyl peptidase i inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: I, J (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2bgn
HIV-1 tat protein derived n-terminal nonapeptide trp2-tat (1-9) bound to the active site of dipeptidyl peptidase iv (cd26)
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Bos taurus. Bovine. Organism_taxid: 9913.
Chains: A, B, C, D (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2bgr
Crystal structure of HIV-1 tat derived nonapeptides tat(1-9) bound to the active site of dipeptidyl peptidase iv (cd26)
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Human immunodeficiency virus type 1. Organism_taxid: 11676
Chains: A, B (729 residues) CATH domains: 2.140.10.30 3.40.50.1820
2bua
Crystal structure of porcine dipeptidyl peptidase iv (cd26) in complex with a low molecular weight inhibitor.
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney cortex
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2bub
Crystal structure of human dipeptidyl peptidase iv (cd26) in complex with a reversed amide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia methanolica. Expression_system_taxid: 33166
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2buc
Crystal structure of porcine dipeptidyl peptidase iv (cd26) in complex with a tetrahydroisoquinoline inhibitor
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney cortex
Chains: A, B, C, D (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2fjp
Human dipeptidyl peptidase iv/cd26 in complex with an inhibi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2g5p
Crystal structure of human dipeptidyl peptidase iv (dppiv) complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 21ac
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2g5t
Crystal structure of human dipeptidyl peptidase iv (dppiv) complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 21ag
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2g63
Crystal structure of human dipeptidyl peptidase iv (dppiv) complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 24b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2gbc
Native dpp-iv (cd26) from rat
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116
Chains: A, B (730 residues) CATH domains: 3.40.50.1820 2.140.10.30
2gbf
Rat dpp-iv with alkynyl cyanopyrrolidine #1
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116
Chains: A, B (730 residues) CATH domains: 3.40.50.1820 2.140.10.30
2gbg
Rat dpp-iv with alkynyl cyanopyrrolidine #2
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116
Chains: A, B (730 residues) CATH domains: 3.40.50.1820 2.140.10.30
2gbi
Rat dpp-iv with xanthine inhibitor 4
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116
Chains: A, B (730 residues) CATH domains: 3.40.50.1820 2.140.10.30
2hha
The structure of dpp4 in complex with an oxadiazole inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2i03
Crystal structure of human dipeptidyl peptidase 4 (dpp iv) with potent alkynyl cyanopyrrolidine (abt-279)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2i3z
Rat dpp-iv with xanthine mimetic inhibitor #7
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116
Chains: A, B (730 residues) CATH domains: 3.40.50.1820 2.140.10.30
2i78
Crystal structure of human dipeptidyl peptidase iv (dpp iv) with abt-341, a cyclohexene-constrained phenethylamine inhi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2iit
Human dipeptidyl peptidase 4 in complex with a diazepan-2-on inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2iiv
Human dipeptidyl peptidase 4 in complex with a diazepan-2-on inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2jid
Human dipeptidyl peptidase iv in complex with 1-(3,4- dimethoxy-phenyl)-3-m-tolyl-piperidine-4-ylamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2oae
Crystal structure of rat dipeptidyl peptidase (dppiv) with thiazole-based peptide mimetic #31
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116
Chains: A, B (730 residues) CATH domains: 3.40.50.1820 2.140.10.30
2oag
Crystal structure of human dipeptidyl peptidase iv (dppiv) w pyrrolidine-constrained phenethylamine 29g
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2ogz
Crystal structure of dpp-iv complexed with lilly aryl ketone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2ole
Crystal structure of human dipeptidyl peptidase iv (dppiv) c with cyclic hydrazine derivatives
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chromosome 2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2onc
Crystal structure of human dpp-4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D (724 residues) CATH domains: 2.140.10.30 3.40.50.1820
2oph
Human dipeptidyl peptidase iv in complex with an alpha amino inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2oqi
Human dipeptidyl peptidase iv (dpp4) with piperidinone- constrained phenethylamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2oqv
Human dipeptidyl peptidase iv (dpp4) with piperidine- constrained phenethylamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
2p8s
Human dipeptidyl peptidase iv/cd26 in complex with a cyclohe inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2qjr
Dipepdyl peptidase iv in complex with inhibitor pzf
Source: Homo sapiens. Human. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda.
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2qky
Complex structure of dipeptidyl peptidase iv and a oxadiazolyl ketone
Source: Homo sapiens. Human. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda.
Chains: A, B, C, D (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2qoe
Human dipeptidyl peptidase iv in complex with a triazolopipe based beta amino acid inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2qt9
Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2qtb
Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
2rgu
Crystal structure of complex of human dpp4 and inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
2rip
Structure of dppiv in complex with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dppiv. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (729 residues) CATH domains: 3.40.50.1820 2.140.10.30
3bjm
Crystal structure of human dpp-iv in complex with (1s,3s, 5s 2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1- yl)acetyl]-2 azabicyclo[3.1.0]hexane-3-carbonitrile (cas), (1s,3s,5s)-2- amino-2-(3-hydroxyadamantan-1- yl)acetyl)-2-azabicyclo[3.1. 3-carbonitrile (iupac), or bms-477118
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3c43
Human dipeptidyl peptidase iv/cd26 in complex with a flouroo inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3c45
Human dipeptidyl peptidase iv/cd26 in complex with a fluoroo inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3ccb
Crystal structure of human dpp4 in complex with a benzimidaz derivative
Source: Homo sapiens. Human. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_cell_line: sf9.
Chains: A, B, C, D (724 residues) CATH domains: 2.140.10.30 3.40.50.1820
3ccc
Crystal structure of human dpp4 in complex with a benzimidaz derivative
Source: Homo sapiens. Human. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_cell_line: sf9.
Chains: A, B, C, D (724 residues) CATH domains: 2.140.10.30 3.40.50.1820
3d4l
Human dipeptidyl peptidase iv/cd26 in complex with a novel i
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3eio
Crystal structure analysis of dppiv inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (726 residues) CATH domains: 3.40.50.1820 2.140.10.30
3f8s
Crystal structure of dipeptidyl peptidase iv in complex with
Source: Homo sapiens. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
3g0b
Crystal structure of dipeptidyl peptidase iv in complex with
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (727 residues) CATH domains: 2.140.10.30 3.40.50.1820
3g0c
Crystal structure of dipeptidyl peptidase iv in complex with pyrimidinedione inhibitor 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (723 residues) CATH domains: 2.140.10.30 3.40.50.1820
3g0d
Crystal structure of dipeptidyl peptidase iv in complex with pyrimidinedione inhibitor 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (723 residues) CATH domains: 2.140.10.30 3.40.50.1820
3g0g
Crystal structure of dipeptidyl peptidase iv in complex with pyrimidinone inhibitor 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (724 residues) CATH domains: 2.140.10.30 3.40.50.1820
3h0c
Crystal structure of human dipeptidyl peptidase iv (cd26) in with a reversed amide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3hab
The structure of dpp4 in complex with piperidine fused benzi 25
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3hac
The structure of dpp-4 in complex with piperidine fused imidazopyridine 34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3kwf
Human dpp-iv with carmegliptin (s)-1-((2s,3s,11bs)-2-amino- 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1- a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3kwh
Structure of human dpp-iv with hts hit (2s,3s,11bs)-3-butyl- dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinol ylamine
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3kwj
Strucutre of human dpp-iv with (2s,3s,11bs)-3-(3-fluoromethy 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoq ylamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3nox
Crystal structure of human dpp-iv in complex with sa-(+)-(6- (aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a] 2-yl)(morpholino)methanone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, hcg_39008. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
3o95
Crystal structure of human dpp4 bound to tak-100
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (727 residues) CATH domains: 2.140.10.30 3.40.50.1820
3o9v
Crystal structure of human dpp4 bound to tak-986
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (727 residues) CATH domains: 2.140.10.30 3.40.50.1820
3oc0
Structure of human dpp-iv with hts hit (2s,3s,11bs)-3-butyl- dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinol ylamine
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
3opm
Crystal structure of human dpp4 bound to tak-294
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (727 residues) CATH domains: 2.140.10.30 3.40.50.1820
3q0t
Crystal structure of human dpp-iv in complex withsa-(+)- met (aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5h-pyr b]pyridin-6(7h)-yl)acetate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
3q8w
A b-aminoacyl containing thiazolidine derivative and dppiv c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (726 residues) CATH domains: 2.140.10.30 3.40.50.1820
3qbj
Crystal structure of dipeptidyl peptidase iv in complex with
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
3sww
Crystal structure of human dpp-iv in complex with sa-(+)-3- (aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2 5h-pyrrolo[3,4-b]pyridin-7(6h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
3sx4
Crystal structure of human dpp-iv in complex with sa-(+)-3- (aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2 5h-pyrrolo[3,4-b]pyridin-7(6h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
3vjk
Crystal structure of human depiptidyl peptidase iv (dpp-4) i with mp-513
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: expressf+.
Chains: A, B (729 residues)
3vjl
Crystal structure of human depiptidyl peptidase iv (dpp-4) i with a prolylthiazolidine inhibitor #2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: expressf+.
Chains: A, B (729 residues)
3vjm
Crystal structure of human depiptidyl peptidase iv (dpp-4) i with a prolylthiazolidine inhibitor #1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: expressf+.
Chains: A, B (729 residues)
3w2t
Crystal structure of human depiptidyl peptidase iv (dpp-4) i with vildagliptin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: expressf+.
Chains: A, B (729 residues) CATH domains: 2.140.10.30 3.40.50.1820
4a5s
Crystal structure of human dpp4 in complex with a noval hete dpp4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
4dsa
Crystal structure of dpp-iv with compound c1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f cell.
Chains: A, B (724 residues) CATH domains: 3.40.50.1820 2.140.10.30
4dsz
Crystal structure of dpp-iv with compound c2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f cell.
Chains: A, B (724 residues) CATH domains: 3.40.50.1820 2.140.10.30
4dtc
Crystal structure of dpp-iv with compound c5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f cell.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
4ffv
Crystal structure of dipeptidyl peptidase iv (dpp4, dpp-iv, complex with 11a19 fab
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: dpp4, cd26. Expressed in: homo sapiens. Expression_system_taxid: 9606. Mus musculus. Mouse. Organism_taxid: 10090.
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
4ffw
Crystal structure of dipeptidyl peptidase iv (dpp4, dpp-iv, complex with fab + sitagliptin
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: dpp4, cd26. Expressed in: homo sapiens. Expression_system_taxid: 9606. Mus musculus. Mouse. Organism_taxid: 10090.
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
4g1f
Crystal structure of human dipeptidyl peptidase iv in comple pyridopyrimidinedione analogue
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (724 residues) CATH domains: 2.140.10.30 3.40.50.1820
4j3j
Crystal structure of dpp-iv with compound c3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f cell.
Chains: A, B (725 residues) CATH domains: 3.40.50.1820 2.140.10.30
4jh0
Crystal structure of dipeptidyl-peptidase 4 (cd26, adenosine complexing protein 2) (dpp-iv-wt) complex with bms-767778 a (aminomethyl)-4-(2,4- dichlorophenyl)-2-methyl-5-oxo-5,7-di pyrrolo[3,4- b]pyridin-6-yl)-n,n-dimethylacetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
4kr0
Complex structure of mers-cov spike rbd bound to cd26
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high5. Human betacoronavirus 2c emc/2012. Organism_taxid: 1235996.
Chain: A (728 residues) CATH domains: 2.140.10.30 3.40.50.1820
4l72
Crystal structure of mers-cov complexed with human dpp4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Mers-cov. Expression_system_taxid: 7108
Chain: A (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
4lko
Crystal structure of human dpp-iv in complex with bms-744891
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30
4n8d
Dpp4 complexed with syn-7aa
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
4n8e
Dpp4 complexed with compound 12a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (727 residues) CATH domains: 3.40.50.1820 2.140.10.30
4pnz
Human dipeptidyl peptidase iv/cd26 in complex with the long- inhibitor omarigliptin (mk-3102)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (728 residues) CATH domains: 3.40.50.1820 2.140.10.30