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PDBsum entry 5n4t
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References listed in PDB file
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Key reference
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Title
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Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-Lactamase inhibition.
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Authors
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G.B.Li,
J.Brem,
R.Lesniak,
M.I.Abboud,
C.T.Lohans,
I.J.Clifton,
S.Y.Yang,
J.C.Jiménez-Castellanos,
M.B.Avison,
J.Spencer,
M.A.Mcdonough,
C.J.Schofield.
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Ref.
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Chem Commun (Camb), 2017,
53,
5806-5809.
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PubMed id
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Abstract
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Crystallographic analyses of the VIM-5 metallo-β-lactamase (MBL) with
isoquinoline inhibitors reveal non zinc ion binding modes. Comparison with other
MBL-inhibitor structures directed addition of a zinc-binding thiol enabling
identification of potent B1 MBL inhibitors. The inhibitors potentiate meropenem
activity against clinical isolates harboring MBLs.
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