PDBsum entry 5kot

Hydrolase/hydrolase inhibitor

PDB id: 5kot

Contents

Protein chains

332 a.a.

Ligands

NAG ×2

6VU ×2

PGE ×2

PEG ×4

DMS ×14

Waters ×290

PDB id:

5kot

Name:

Hydrolase/hydrolase inhibitor

Title:

Discovery of tak-272: a novel, potent and orally active renin in- hibitor

Structure:

Renin. Chain: a, b. Fragment: unp residues 70-406. Synonym: angiotensinogenase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293

Resolution:

2.10Å R-factor: 0.178 R-free: 0.203

Authors:

G.P.Snell,C.A.Behnke,K.Okada,O.Hideyuki,B.-C.Sang,W.Lane

Key ref:

Y.Imaeda et al. Discovery of tak-272: a novel, Potent and orally acti renin inhibitor. To be published, .

Date:

01-Jul-16 Release date: 05-Jul-17

Protein chains

P00797  (RENI_HUMAN) -  Renin from Homo sapiens

Seq: 406 a.a.

Struc: 332 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.15 - renin.
• Reaction: Cleaves Leu-|- bond in angiotensinogen to generate angiotensin I.