_EC 3.4.23.15 Renin. 69 PDB entries  
EC 3.-.-.- Hydrolases. [21,295 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,892 PDB entries]
EC 3.4.23.- Aspartic endopeptidases. [1,474 PDB entries]
EC 3.4.23.15 Renin. [69 PDB entries]    
1bbs

Reaction: Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
Other name(s): Angiotensin-forming enzyme. Angiotensinogenase.
Comments: Belongs to peptidase family A1. Formerly Ec 3.4.4.15 and Ec 3.4.99.19.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 69 PDB entries in enzyme class E.C.3.4.23.15

  PDB code Protein
1bbs
X-ray analyses of peptide inhibitor complexes define the structural basis of specificity for human and mouse renins
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (331 residues) CATH domains: 2.40.70.10 2.40.70.10
1bil
Crystallographic studies on the binding modes of p2-p3 butan renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cmv ie-human preprorenin cdna, ren. Expressed in: stably transferred dog epithelial cell.
Chains: A, B (334 residues) CATH domains: 2.40.70.10 2.40.70.10
1bim
Crystallographic studies on the binding modes of p2-p3 butan renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cmv ie-human preprorenin cdna, ren. Expressed in: canis lupus familiaris. Expression_system_taxid: 9615. Other_details: stably transferred
Chains: A, B (334 residues) CATH domains: 2.40.70.10 2.40.70.10
1hrn
High resolution crystal structures of recombinant human reni complex with polyhydroxymonoamide inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (335 residues) CATH domains: 2.40.70.10 2.40.70.10
1rne
The crystal structure of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: ovary
Chain: A (330 residues) CATH domains: 2.40.70.10 2.40.70.10
1smr
The 3-d structure of mouse submaxillary renin complexed with decapeptide inhibitor ch-66 based on the 4-16 fragment of r angiotensinogen
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: cdna.
Chains: A, C, E, G (331 residues) CATH domains: 2.40.70.10 2.40.70.10
2bks
Crystal structure of renin-pf00074777 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (330 residues) CATH domains: 2.40.70.10 2.40.70.10
2bkt
Crystal structure of renin-pf00257567 complex
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (330 residues) CATH domains: 2.40.70.10 2.40.70.10
2fs4
Ketopiperazine-based renin inhibitors: optimization of the c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (329 residues) CATH domains: 2.40.70.10 2.40.70.10
2g1n
Ketopiperazine-based renin inhibitors: optimization of the "
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
2g1o
Ketopiperazine-based renin inhibitors: optimization of the "
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
2g1r
Ketopiperazine-based renin inhibitors: optimization of the c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
2g1s
Ketopiperazine-based renin inhibitors: optimization of the c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
2g1y
Ketopiperazine-based renin inhibitors: optimization of the "
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
2g20
Ketopiperazine-based renin inhibitors: optimization of the c ring
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
2g21
Ketopiperazine-based renin inhibitors: optimization of the "c" ring
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (329 residues) CATH domains: 2.40.70.10 2.40.70.10
2g22
Ketopiperazine-based renin inhibitors: optimization of the "
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
2g24
Ketopiperazine-based renin inhibitors: optimization of the "c" ring
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (329 residues) CATH domains: 2.40.70.10 2.40.70.10
2g26
Ketopiperazine-based renin inhibitors: optimization of the "c" ring
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (329 residues) CATH domains: 2.40.70.10 2.40.70.10
2g27
Ketopiperazine-based renin inhibitors: optimization of the "c" ring
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (328 residues) CATH domains: 2.40.70.10 2.40.70.10
2i4q
Human renin/pf02342674 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (336 residues) CATH domains: 2.40.70.10 2.40.70.10
2iko
Crystal structure of human renin complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chains: A, B (338 residues) CATH domains: 2.40.70.10 2.40.70.10
2iku
Crystal structure of human renin complexed with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
2il2
Crystal structure of human renin complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chains: A, B (338 residues) CATH domains: 2.40.70.10 2.40.70.10
2ren
Structure of recombinant human renin, a target for cardiovas active drugs, at 2.5 angstroms resolution
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (320 residues) CATH domains: 2.40.70.10 2.40.70.10
2v0z
Crystal structure of renin with inhibitor 10 (aliskiren)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chains: C, O (339 residues) CATH domains: 2.40.70.10 2.40.70.10
2v10
Crystal structure of renin with inhibitor 9
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chains: C, O (334 residues) CATH domains: 2.40.70.10 2.40.70.10
2v11
Crystal structure of renin with inhibitor 6
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chains: C, O (334 residues) CATH domains: 2.40.70.10 2.40.70.10
2v12
Crystal structure of renin with inhibitor 8
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chains: C, O (334 residues) CATH domains: 2.40.70.10 2.40.70.10
2v13
Crystal structure of renin with inhibitor 7
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chain: A (330 residues) CATH domains: 2.40.70.10 2.40.70.10
2v16
Crystal structure of renin with inhibitor 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chains: C, O (334 residues) CATH domains: 2.40.70.10 2.40.70.10
2x0b
Crystal structure of human angiotensinogen complexed with re
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, E, G (330 residues)
3d91
Human renin in complex with remikiren
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren
Chains: A, B (334 residues) CATH domains: 2.40.70.10 2.40.70.10
3g6z
Design and preparation of potent, non-peptidic, bioavailable inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cell
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3g70
Design and preparation of potent, non-peptidic, bioavailable inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cell
Chains: A, B (334 residues) CATH domains: 2.40.70.10 2.40.70.10
3g72
Design and preparation of potent, non-peptidic, bioavailable inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cell
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
3gw5
Crystal structure of human renin complexed with a novel inhi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293.
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3k1w
New classes of potent and bioavailable human renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: cho cell
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
3km4
Optimization of orally bioavailable alkyl amine renin inhibi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human_renin, ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 cells.
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3o9l
Design and optimisation of new piperidines as renin inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B, C, D (162 residues) CATH domain: 2.40.70.10
3oad
Design and optimization of new piperidines as renin inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B, C, D (162 residues) CATH domain: 2.40.70.10
3oag
Design and optimization of new piperidines as renin inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B, C, D (162 residues) CATH domain: 2.40.70.10
3oot
Crystal structure analysis of renin-indole-piperazin inhibit complexes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cell (c
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3oqf
Crystal structure analysis of renin-indole-piperazine inhibi complexes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cell (c
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3oqk
Crystal structure analysis of renin-indole-piperazin inhibit complexes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cell (c
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3own
Potent macrocyclic renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (334 residues) CATH domains: 2.40.70.10 2.40.70.10
3q3t
Alkyl amine renin inhibitors: filling s1 from s3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren, renin. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3q4b
Clinically useful alkyl amine renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren, renin. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293.
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3q5h
Clinically useful alkyl amine renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren, renin. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293.
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3sfc
Structure-based optimization of potent 4- and 6-azaindole-3- carboxamides as renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek
Chains: A, B (340 residues) CATH domains: 2.40.70.10 2.40.70.10
3vcm
Crystal structure of human prorenin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek. Expression_system_cell_line: hek
Chains: A, B, P, Q (335 residues) CATH domains: 2.40.70.10 2.40.70.10
3vsw
Human renin in complex with compound 8
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f.
Chains: A, B (340 residues) CATH domains: 2.40.70.10 2.40.70.10
3vsx
Human renin in complex with compound 18
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f.
Chains: A, B (340 residues) CATH domains: 2.40.70.10 2.40.70.10
3vuc
Human renin in complex with compound 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f.
Chains: A, B (340 residues) CATH domains: 2.40.70.10 2.40.70.10
3vyd
Human renin in complex with inhibitor 6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f.
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
3vye
Human renin in complex with inhibitor 7
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f.
Chains: A, B (335 residues) CATH domains: 2.40.70.10 2.40.70.10
3vyf
Human renin in complex with inhibitor 9
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f.
Chains: A, B (336 residues) CATH domains: 2.40.70.10 2.40.70.10
4amt
Crystal structure at 2.6a of human prorenin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 ebna.
Chain: A (349 residues) CATH domains: 2.40.70.10 2.40.70.10
4gj5
Crystal structure of renin in complex with nvp-amq838 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (332 residues) CATH domains: 2.40.70.10 2.40.70.10
4gj6
Crystal structure of renin in complex with nvp-ayz832 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
4gj7
Crystal structure of renin in complex with nvp-bca079 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (335 residues) CATH domains: 2.40.70.10 2.40.70.10
4gj8
Crystal structure of renin in complex with pkf909-724 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (334 residues) CATH domains: 2.40.70.10 2.40.70.10
4gj9
Crystal structure of renin in complex with gp055321 (compoun
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (333 residues) CATH domains: 2.40.70.10 2.40.70.10
4gja
Crystal structure of renin in complex with nvp-ayl747 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
4gjb
Crystal structure of renin in complex with nvp-bbv031 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (335 residues) CATH domains: 2.40.70.10 2.40.70.10
4gjc
Crystal structure of renin in complex with nvp-bch965 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (337 residues) CATH domains: 2.40.70.10 2.40.70.10
4gjd
Crystal structure of renin in complex with nvp-bgq311 (compo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (335 residues) CATH domains: 2.40.70.10 2.40.70.10
4pyv
Crystal structure of renin in complex with compound4
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chains: A, B (335 residues)
4q1n
Structure-based design of 4-hydroxy-3,5-substituted piperidi direct renin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek
Chains: A, B (336 residues) CATH domains: 2.40.70.10 2.40.70.10