PDBsum entry 5gmf

Immune system/RNA

PDB id: 5gmf

Contents

Protein chains

776 a.a.

DNA/RNA

Ligands

NAG-NAG ×6

NAG ×18

GMP ×4

Metals

_CA ×4

Waters ×157

PDB id:

5gmf

Name:

Immune system/RNA

Title:

Crystal structure of monkey tlr7 in complex with guanosine and polyu

Structure:

Toll-like receptor 7. Chain: a, b, c, d. Fragment: unp residues 27-839. Synonym: uncharacterized protein. Engineered: yes. Mutation: yes. RNA (5'-r(p Up Up Up U)-3'). Chain: e, f, g, h. Engineered: yes

Source:

Macaca mulatta. Rhesus macaque. Organism_taxid: 9544. Gene: tlr7. Expressed in: drosophila. Expression_system_taxid: 7215. Synthetic: yes. Homo sapiens. Organism_taxid: 9606

Resolution:

2.50Å R-factor: 0.210 R-free: 0.243

Authors:

Z.Zhang,U.Ohto,T.Shimizu

Key ref:

Z.Zhang et al. (2016). Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA. Immunity, 45, 737-748. PubMed id: 27742543 DOI: 10.1016/j.immuni.2016.09.011

Date:

14-Jul-16 Release date: 02-Nov-16

Protein chains

B3Y653  (B3Y653_MACMU) -  Toll-like receptor 7 from Macaca mulatta

Seq: 1049 a.a.

Struc: 776 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

DNA/RNA chains

U-U-U-U 4 bases

U-U-U-U 4 bases

U-U-U-U 4 bases

U-U-U-U 4 bases

DOI no: 10.1016/j.immuni.2016.09.011

Immunity 45:737-748 (2016)

PubMed id: 27742543

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

Z.Zhang, U.Ohto, T.Shibata, E.Krayukhina, M.Taoka, Y.Yamauchi, H.Tanji, T.Isobe, S.Uchiyama, K.Miyake, T.Shimizu.

ABSTRACT

No abstract given.