PDBsum entry 5d0u

Hydrolase

PDB id: 5d0u

Contents

Protein chain

705 a.a.

Ligands

ADP

DMS ×9

Metals

_MG

Waters ×4

References listed in PDB file

Key reference

• Title: Structural and functional analysis of the RNA helicase prp43 from the thermophilic eukaryote chaetomium thermophilum.
• Authors: M.J.Tauchert, J.B.Fourmann, H.Christian, R.Lührmann, R.Ficner.
• Ref.: Acta Crystallogr F Struct Biol Commun, 2016, 72, 112-120. [DOI no: 10.1107/S2053230X15024498]
• PubMed id: 26841761

Abstract

RNA helicases are indispensable for all organisms in each domain of life and have implications in numerous cellular processes. The DEAH-box RNA helicase Prp43 is involved in pre-mRNA splicing as well as rRNA maturation. Here, the crystal structure of Chaetomium thermophilum Prp43 at 2.9 Å resolution is revealed. Furthermore, it is demonstrated that Prp43 from C. thermophilum is capable of functionally replacing its orthologue from Saccharomyces cerevisiae in spliceosomal disassembly assays.