PDBsum entry 5aer

Signaling protein

PDB id: 5aer

Contents

Protein chains

181 a.a.

14 a.a.

Metals

__K

_CA ×3

Waters ×30

PDB id:

5aer

Name:

Signaling protein

Title:

Neuronal calcium sensor-1 (ncs-1)from rattus norvegicus complex with d2 dopamine receptor peptide from homo sapiens

Structure:

Neuronal calcium sensor 1. Chain: a. Synonym: ncs-1, frequenin homolog, frequenin-like protein, frequenin- like ubiquitous protein, neuronal calcium sensor-1. Engineered: yes. D(2) dopamine receptor. Chain: b, c. Synonym: dopamine d2 receptor. Engineered: yes.

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: neuron. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human.

Resolution:

2.19Å R-factor: 0.221 R-free: 0.256

Authors:

M.Saleem,V.Karuppiah,S.Pandalaneni,R.Burgoyne,J.P.Derrick,L.Y.Lian

Key ref:

S.Pandalaneni et al. (2015). Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions. J Biol Chem, 290, 18744-18756. PubMed id: 25979333 DOI: 10.1074/jbc.M114.627059

Date:

08-Jan-15 Release date: 18-Feb-15

Supersedes:

2you

Protein chain

P62168  (NCS1_RAT) -  Neuronal calcium sensor 1 from Rattus norvegicus

Seq: 190 a.a.

Struc: 181 a.a.

Protein chains

P14416  (DRD2_HUMAN) -  D(2) dopamine receptor from Homo sapiens

Seq: 443 a.a.

Struc: 14 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DOI no: 10.1074/jbc.M114.627059

J Biol Chem 290:18744-18756 (2015)

PubMed id: 25979333

Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.

S.Pandalaneni, V.Karuppiah, M.Saleem, L.P.Haynes, R.D.Burgoyne, O.Mayans, J.P.Derrick, L.Y.Lian.

ABSTRACT

No abstract given.