PDBsum entry 5wxt

Hydrolase/hydrolase inhibitor

PDB id: 5wxt

Contents

Protein chain

245 a.a.

Ligands

7YR

Waters ×52

PDB id:

5wxt

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of upa-s195a in complex with s2444

Structure:

Urokinase-type plasminogen activator chain b. Chain: u. Synonym: upa. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922

Resolution:

2.10Å R-factor: 0.216 R-free: 0.266

Authors:

L.Jiang,M.Huang

Key ref:

L.Jiang and m.huang Crystal structure of upa-S195a in complex with s2444. To be published, .

Date:

08-Jan-17 Release date: 11-Jul-18

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 245 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.