PDBsum entry 5pb5

Hydrolase/hydrolase inhibitor

PDB id: 5pb5

Contents

Protein chains

57 a.a.

247 a.a.

Ligands

GOL

9RY

SO4 ×2

Metals

_CA

_CL

Waters ×314

PDB id:

5pb5

Name:

Hydrolase/hydrolase inhibitor

Title:

Human factor viia in complex with 1-[[3-[5-hydroxy-4-(7h-pyrrolo[2,3- d]pyrimidin-6-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 1.84a

Structure:

Coagulation factor vii light chain. Chain: a. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes. Coagulation factor vii heavy chain. Chain: b. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.84Å R-factor: 0.186 R-free: 0.200

Authors:

M.Stihle,A.Mayweg,S.Roever,M.G.Rudolph

Key ref:

A.Mayweg et al. Crystal structure of a factor viia complex. To be published, .

Date:

16-Nov-16 Release date: 21-Jun-17

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 57 a.a.

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 247 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.