EC 3.4.21.21 - Coagulation factor VIIa

  IntEnz view ENZYME view
XML

IntEnz Enzyme Nomenclature
EC 3.4.21.21

Names

Accepted name:
coagulation factor VIIa
Other names:
activated blood coagulation factor VII
blood-coagulation factor VIIa
Systematic name:

Reaction

Comments:

Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003802
CAS Registry Number: 65312-43-8
UniProtKB/Swiss-Prot:

References

  1. Nemerson, Y. and Esnouf, M.P.
    Activation of a proteolytic system by a membrane lipoprotein: mechanism of action of tissue factor.
    Proc. Natl. Acad. Sci. USA 70: 310-314 (1973). [PMID: 4510277]
  2. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W.
    The role of serine proteases in the blood coagulation cascade.
    Adv. Enzymol. 48: 277-318 (1979). [PMID: 367103]
  3. Jackson, C.M. and Nemerson, Y.
    Blood coagulation.
    Annu. Rev. Biochem. 49: 765-811 (1980). [PMID: 6996572]
  4. Broze, G.J., Jr. and Majerus, P.W.
    Human factor VII.
    Methods Enzymol. 80: 228-237 (1981).

[EC 3.4.21.21 created 1978]