PDBsum entry 5pb0

Hydrolase/hydrolase inhibitor

PDB id: 5pb0

Contents

Protein chains

56 a.a.

250 a.a.

Ligands

SO4 ×5

GOL

7LX

Metals

_CL ×3

_CA

Waters ×355

PDB id:

5pb0

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of factor viia in complex with 2-(4-ethoxy-3- methoxyphenyl)-2-(isoquinolin-6-ylamino)acetic acid

Structure:

Coagulation factor vii light chain. Chain: a. Fragment: factor vii residues 148-466. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes. Coagulation factor vii heavy chain. Chain: b. Fragment: factor vii residues 148-466. Synonym: proconvertin,serum prothrombin conversion accelerator,spca.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.98Å R-factor: 0.169 R-free: 0.193

Authors:

M.Stihle,A.Mayweg,S.Roever,M.G.Rudolph

Key ref:

A.Mayweg et al. Crystal structure of a factor viia complex. To be published, .

Date:

10-Nov-16 Release date: 21-Jun-17

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 56 a.a.

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 250 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.