PDBsum entry 5pao

Hydrolase/hydrolase inhibitor

PDB id: 5pao

Contents

Protein chains

56 a.a.

247 a.a.

Ligands

SO4 ×5

GOL ×2

7Z7

Metals

_CL

_CA

Waters ×332

PDB id:

5pao

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of factor viia in complex with (2s)-2,3-dihydroxy-n- [[3-[5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- yl]phenyl]methyl]propanamide;hydrobromide

Structure:

Coagulation factor vii light chain. Chain: a. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes. Coagulation factor vii heavy chain. Chain: c. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.40Å R-factor: 0.179 R-free: 0.188

Authors:

M.Stihle,A.Mayweg,S.Roever,M.G.Rudolph

Key ref:

A.Mayweg et al. Crystal structure of a factor viia complex. To be published, .

Date:

10-Nov-16 Release date: 21-Jun-17

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 56 a.a.

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 247 a.a.

Enzyme reactions

• Enzyme class: Chains A, C: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.