PDBsum entry 5pab

Hydrolase/hydrolase inhibitor

PDB id: 5pab

Contents

Protein chains

248 a.a.

55 a.a.

Ligands

7XD

GOL ×4

SO4 ×2

Metals

_CL ×3

_CA

Waters ×288

PDB id:

5pab

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of factor viia in complex with 1-[[3-[2-hydroxy-3- (1h-pyrrolo[3,2-c]pyridin-2-yl)phenyl]phenyl]methyl]-3-phenylurea

Structure:

Coagulation factor vii heavy chain. Chain: h. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes. Coagulation factor vii light chain. Chain: l. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.99Å R-factor: 0.188 R-free: 0.220

Authors:

M.Stihle,A.Mayweg,S.Roever,M.G.Rudolph

Key ref:

A.Mayweg et al. Crystal structure of a factor viia complex. To be published, .

Date:

10-Nov-16 Release date: 21-Jun-17

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 248 a.a.*

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 55 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains H, L: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.