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PDBsum entry 5o5r
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PDB id:
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Hydrolase
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Title:
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X-ray structure of human glutamate carboxypeptidase ii (gcpii) in complex with a urea based inhibitor psma 1023
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Structure:
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Glutamate carboxypeptidase 2. Chain: a. Synonym: cell growth-inhibiting gene 27 protein,folate hydrolase 1, folylpoly-gamma-glutamate carboxypeptidase,fgcp,glutamate carboxypeptidase ii,gcpii,membrane glutamate carboxypeptidase,mgcp,n- acetylated-alpha-linked acidic dipeptidase i,naaladase i,prostate- specific membrane antigen,psma,pteroylpoly-gamma-glutamate carboxypeptidase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: folh1, folh, naalad1, psm, psma, gig27. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneiders s2 cells.
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Resolution:
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1.65Å
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R-factor:
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0.126
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R-free:
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0.160
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Authors:
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L.Motlova,Z.Novakova,C.Barinka
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Key ref:
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L.Motlova
et al.
X-Ray structure of human glutamate carboxypeptidase i (gcpii) in complex with a urea based inhibitor psma 1.
To be published,
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Date:
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02-Jun-17
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Release date:
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13-Jun-18
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PROCHECK
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Headers
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References
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Q04609
(FOLH1_HUMAN) -
Glutamate carboxypeptidase 2 from Homo sapiens
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Seq:
Struc:
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750 a.a.
696 a.a.
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Enzyme class:
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E.C.3.4.17.21
- glutamate carboxypeptidase Ii.
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Reaction:
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Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
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Cofactor:
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Zn(2+)
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Links
