PDBsum entry 5l2z

Hydrolase/hydrolase inhibitor

PDB id: 5l2z

Contents

Protein chains

254 a.a.

58 a.a.

Ligands

70C

SO4 ×3

GOL ×2

Metals

_CA

Waters ×334

PDB id:

5l2z

Name:

Hydrolase/hydrolase inhibitor

Title:

Factor viia in complex with the inhibitor 1-[(2r,15r)-2-[(1-amino-4- fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4, 11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19- hexaen-7-yl]cyclohexane-1-carboxylic acid

Structure:

Coagulation factor vii (heavy chain). Chain: h. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes. Coagulation factor vii (light chain). Chain: l. Synonym: proconvertin,serum prothrombin conversion accelerator,spca. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026

Resolution:

1.79Å R-factor: 0.183 R-free: 0.203

Authors:

A.Wei

Key ref:

V.U.Ladziata et al. (2016). Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg Med Chem Lett, 26, 5051-5057. PubMed id: 27612545 DOI: 10.1016/j.bmcl.2016.08.088

Date:

02-Aug-16 Release date: 28-Sep-16

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 254 a.a.

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 58 a.a.

Enzyme reactions

• Enzyme class: Chains H, L: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.

DOI no: 10.1016/j.bmcl.2016.08.088

Bioorg Med Chem Lett 26:5051-5057 (2016)

PubMed id: 27612545

Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.

V.U.Ladziata, P.W.Glunz, Y.Zou, X.Zhang, W.Jiang, S.Jacutin-Porte, D.L.Cheney, A.Wei, J.M.Luettgen, T.M.Harper, P.C.Wong, D.Seiffert, R.R.Wexler, E.S.Priestley.

ABSTRACT

No abstract given.