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PDBsum entry 4d76
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PDB id:
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Hydrolase
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Title:
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Human fxia in complex with small molecule inhibitors.
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Structure:
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Coagulation factor xi. Chain: a. Fragment: catalytic domain, residues 388-625. Synonym: fxi, plasma thromboplastin antecedent, pta, coagulation factor xia. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Resolution:
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1.77Å
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R-factor:
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0.184
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R-free:
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0.210
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Authors:
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J.Sandmark,L.Oster,T.Jacso,V.Ullah,A.Redzick,U.Borjesson,T.Olsson, M.Norberg,T.Akerud
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Key ref:
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T.Jacso
et al.
From mm fragments to nm compounds using iloe-Nmr to g linking of compounds in fragment based drug discovery (fbdd)..
To be published,
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Date:
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20-Nov-14
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Release date:
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20-Jan-16
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PROCHECK
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Headers
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References
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P03951
(FA11_HUMAN) -
Coagulation factor XI from Homo sapiens
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Seq:
Struc:
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625 a.a.
236 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 4 residue positions (black
crosses)
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Enzyme class:
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E.C.3.4.21.27
- coagulation factor XIa.
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Reaction:
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Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
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Links
