EC 18.104.22.168 - Coagulation factor XIa
IntEnz Enzyme Nomenclature
activated plasma thromboplastin antecedent
blood-coagulation factor XIa
plasma thromboplastin antecedent
- Selective cleavage of Arg┼Ala and Arg┼Val bonds in factor IX to form factor IXa.
In peptidase family S1 (trypsin family), and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa.
Links to other databases
Human factor XI (plasma thromboplastin antecedent).Methods Enzymol. 80C: 211-220 (1981).
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.Biochemistry 23: 644-650 (1984). [PMID: 6370301]
Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.Biochemistry 25: 2417-2424 (1986). [PMID: 3636155]
[EC 22.214.171.124 created 1978]