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PDBsum entry 4crf
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PDB id:
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Hydrolase
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Title:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Structure:
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Coagulation factor xia light chain. Chain: a. Fragment: catalytic domain, residues 388-625. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Resolution:
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2.30Å
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R-factor:
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0.184
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R-free:
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0.244
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Authors:
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J.Sandmark,L.Oster,O.Fjellstrom,S.Akkaya,H.G.Beisel,P.O.Eriksson, K.Erixon,D.Gustafsson,U.Jurva,D.Kang,D.Karis,W.Knecht,V.Nerme, I.Nilsson,T.Olsson,A.Redzic,R.Roth,A.Tigerstrom
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Date:
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26-Feb-14
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Release date:
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11-Feb-15
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PROCHECK
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Headers
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References
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P03951
(FA11_HUMAN) -
Coagulation factor XI from Homo sapiens
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Seq:
Struc:
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625 a.a.
238 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 4 residue positions (black
crosses)
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Enzyme class:
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E.C.3.4.21.27
- coagulation factor XIa.
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Reaction:
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Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
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Links
