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PDBsum entry 4ajd
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PDB id:
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Hydrolase
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Title:
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Identification and structural characterization of pde10 fragment inhibitors
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Structure:
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Camp and camp-inhibited cgmp 3', 5'-cyclic phosphodiesterase 10a, pde10. Chain: a, d. Fragment: catalytic domain, residues 439-764. Synonym: phosphodiesterase 10a. Engineered: yes
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Source:
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Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.30Å
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R-factor:
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0.190
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R-free:
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0.246
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Authors:
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P.Johansson,J.S.Albert,L.Spadola,T.Akerud,E.Back,P.Hillertz, R.Horsefeld,C.Scott,N.Spear,G.Tian,A.Tigerstrom,D.Aharony, S.Geschwindner
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Key ref:
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P.Johansson
et al.
Identification and structural characterization of pde fragment inhibitors.
To be published,
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Date:
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16-Feb-12
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Release date:
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06-Mar-13
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PROCHECK
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Headers
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References
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Q9Y233
(PDE10_HUMAN) -
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A from Homo sapiens
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Seq:
Struc:
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1055 a.a.
324 a.a.*
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Key: |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.1.4.17
- 3',5'-cyclic-nucleotide phosphodiesterase.
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Reaction:
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a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H+
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nucleoside 3',5'-cyclic phosphate
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+
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H2O
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=
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nucleoside 5'-phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
