_EC 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase. 101 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.1.-.- Acting on ester bonds. [5,979 PDB entries]
EC 3.1.4.- Phosphoric diester hydrolases. [451 PDB entries]
EC 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase. [101 PDB entries]    
1fl4

Reaction: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
 


Nucleoside 3',5'-cyclic phosphate
+ H(2)O
=
nucleoside 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Cyclic Amp phosphodiesterase.
Comments: Acts on 3',5'-cyclic Amp, 3',5'-cyclic dAMP, 3',5'-cyclic imp, 3',5'-cyclic Gmp and 3',5'-cyclic cmp.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 101 PDB entries in enzyme class E.C.3.1.4.17

  PDB code Protein
1fl4
Theoretical model of bovine phosphodiesterase 5 1st gaf domain
Source: Bos taurus. Bovine
Chain: A (192 residues)
1jp1
Molecular docking of competitive phosphodiesterase substrate cyclic adenosine 3',5'-monophosphate (camp)
Source: Homo sapiens. Human. Expressed in: escherichia coli.
Chain: A (351 residues)
Bound ligand:   Het Group CMP is 52.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
1jp2
Molecular docking of competitive phosphodiesterase inhibitor, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2- pyrrolidinone, rolipram
Source: Homo sapiens. Human. Expressed in: escherichia coli.
Chain: A (351 residues)
1lhq
Catalytic domain of 3',5'-cyclic phosphodiesterase 8a
Source: Homo sapiens. Human. Other_details: gene: pde8a
Chain: A (340 residues)
1lrb
Catalytic domain of human phosphodiesterase 10a
Source: Homo sapiens. Human
Chain: A (257 residues)
1lrc
Catalytic domain of human phosphodiesterase 3a
Source: Homo sapiens. Human
Chain: A (206 residues)
1lxq
Theoretical model of 3',5'-cyclic nucleotide phosphodiesterase 1a
Source: Homo sapiens. Human
Chain: A (279 residues)
1lxr
Theoretical model of the catalytic domain of 3',5'-cyclic nucleotide phosphodiesterase 1b
Source: Homo sapiens. Human
Chain: A (304 residues)
1lxs
Theoretical model of the catalytic domain of 3',5'-cyclic nucleotide phosphodiesterase 1c
Source: Homo sapiens. Human
Chain: A (298 residues)
1lxu
Theoretical model of the catalytic domain of camp-specific 3',5'-cyclic phosphodiesterase 4c
Source: Homo sapiens. Human
Chain: A (344 residues)
1lxw
Theoretical model of the catalytic domain of camp-specific 3',5'-cyclic phosphodiesterase 7b
Source: Homo sapiens. Human
Chain: A (330 residues)
1lxx
Theoretical model of the catalytic domain of 3',5'-cyclic phosphodiesterase 8a
Source: Homo sapiens. Human
Chain: A (334 residues)
1mc0
Regulatory segment of mouse 3',5'-cyclic nucleotide phosphod 2a, containing the gaf a and gaf b domains
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: pde2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (341 residues) CATH domains: 3.30.450.40 3.30.450.40
Bound ligand:   Het Group PCG is 50.00% similar to enzyme reactant Nucleoside
1oym
Crystal structure of pde4d2 in complex with (r)-rolipram
Source: Homo sapiens. Human. Expressed in: escherichia coli.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
1rko
Structure of pde4d2-ibmx
Source: Homo sapiens. Human. Gene: pde4d. Expressed in: escherichia coli.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
1so2
Catalytic domain of human phosphodiesterase 3b in complex with a dihydropyridazine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde3b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (363 residues) CATH domain: 1.10.1300.10
1soj
Catalytic domain of human phosphodiesterase 3b in complex with ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde3b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (364 residues) CATH domain: 1.10.1300.10
1taz
Catalytic domain of human phosphodiesterase 1b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde1b, pde1b1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (322 residues) CATH domain: 1.10.1300.10
1z1l
The crystal structure of the phosphodiesterase 2a catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (338 residues) CATH domain: 1.10.1300.10
2dxl
Glycerophosphodiesterase from enterobacter aerogenes
Source: Enterobacter aerogenes. Organism_taxid: 548. Gene: gpdq. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (271 residues) CATH domains: Unassigned Unassigned
2dxn
Glycerophosphodiesterase from enterobacter aerogenes
Source: Enterobacter aerogenes. Organism_taxid: 548. Gene: gpdq. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (271 residues) CATH domains: Unassigned Unassigned
2e4s
Crystal structure of thE C-terminal gaf domain of human phosphodiesterase 10a
Source: Homo sapiens. Human. Expressed in: cell-free protein synthesis (escherichia coli).
Chains: A, B (177 residues) CATH domain: 3.30.450.40
Bound ligand:   Het Group CMP is 52.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
2hy1
Crystal structure of rv0805
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: rv0805. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (227 residues) CATH domain: 3.60.21.10
2hyo
Crystal structure of rv0805 n97a mutant
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: rv0805. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (227 residues) CATH domain: 3.60.21.10
2hyp
Crystal structure of rv0805 d66a mutant
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: icc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (230 residues) CATH domain: 3.60.21.10
2o8h
Crystal structure of the catalytic domain of rat phosphodiesterase 10a
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pde10a, pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: A (307 residues) CATH domain: 1.10.1300.10
2oun
Crystal structure of pde10a2 in complex with amp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group AMP is 54.00% similar to enzyme product nucleoside 5'-phosphate
2oup
Crystal structure of pde10a
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
2ouq
Crystal structure of pde10a2 in complex with gmp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 5GP is 52.00% similar to enzyme product nucleoside 5'-phosphate
2our
Crystal structure of pde10a2 mutant d674a in complex with camp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group CMP is 52.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
2ous
Crystal structure of pde10a2 mutant d674a
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
2ouu
Crystal structure of pde10a2 mutant d674a in complex with cgmp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (329 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 35G is 50.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
2ouv
Crystal structure of pde10a2 mutant of d564n
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (325 residues) CATH domain: 1.10.1300.10
2ouy
Crystal structure of pde10a2 mutant d564a in complex with camp.
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group CMP is 52.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
2ovv
Crystal structure of the catalytic domain of rat phosphodies
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pde10a, pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (304 residues) CATH domain: 1.10.1300.10
2ovy
Crystal structure of the catalytic domain of rat phosphodies
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pde10a, pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
2r8q
Structure of lmjpdeb1 in complex with ibmx
Source: Leishmania major. Organism_taxid: 5664. Gene: pdeb1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (335 residues) CATH domain: 1.10.1300.10
2wey
Human pde-papaverine complex obtained by ligand soaking of cross-linked protein crystals
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
2y0j
Triazoloquinazolines as a novel class of phosphodiesterase 1 (pde10a) inhibitors, part 2, lead-optimisation.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (314 residues)
2zmf
Crystal structure of thE C-terminal gaf domain of human phosphodiesterase 10a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: cell free (escherichia coli).
Chains: A, B (177 residues) CATH domain: 3.30.450.40
Bound ligand:   Het Group CMP is 52.17% similar to enzyme reactant Nucleoside
2zo9
Malonate-bound structure of the glycerophosphodiesterase fro enterobacter aerogenes (gpdq) and characterization of the n metal ion preference
Source: Enterobacter aerogenes. Organism_taxid: 548. Gene: gpdq. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, C (271 residues) CATH domains: Unassigned Unassigned
2zoa
Malonate-bound structure of the glycerophosphodiesterase fro enterobacter aerogenes (gpdq) collected at 1.280 angstrom
Source: Enterobacter aerogenes. Organism_taxid: 548. Gene: gpdq. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (271 residues) CATH domains: Unassigned Unassigned
3d03
1.9a structure of glycerophoshphodiesterase (gpdq) from enterobacter aerogenes
Source: Enterobacter aerogenes. Aerobacter aerogenes. Organism_taxid: 548. Gene: gpdq. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (274 residues) CATH domains: Unassigned Unassigned
3hqw
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues) CATH domain: 1.10.1300.10
3hqy
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
3hqz
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
3hr1
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
3ib7
Crystal structure of full length rv0805
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv0805. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (295 residues) CATH domain: Unassigned
3ib8
Crystal structure of full length rv0805 in complex with 5'-a
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv0805. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (295 residues) CATH domain: Unassigned
3ibj
X-ray structure of pde2a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (661 residues) CATH domains: 3.30.450.40 3.30.450.40 1.10.1300.10
3itm
Catalytic domain of hpde2a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde2a, pde2a 579-919. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (307 residues) CATH domain: 1.10.1300.10
3itu
Hpde2a catalytic domain complexed with ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (338 residues) CATH domain: 1.10.1300.10
3lxg
Crystal structure of rat phosphodiesterase 10a in complex wi web-3
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: baculovirus. Expression_system_taxid: 10469. Expression_system_cell: sf9 insect cells
Chain: A (308 residues) CATH domain: 1.10.1300.10
3qpn
Structure of pde10-inhibitor complex
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (305 residues) CATH domain: 1.10.1300.10
3qpo
Structure of pde10-inhibitor complex
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (305 residues) CATH domain: 1.10.1300.10
3qpp
Structure of pde10-inhibitor complex
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (305 residues) CATH domain: 1.10.1300.10
3sn7
Highly potent, selective, and orally active phosphodiestaras inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
3sni
Highly potent, selective, and orally active phosphodiestaras inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
3snl
Highly potent, selective, and orally active phosphodiestaras inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
3ui7
Discovery of orally active pyrazoloquinoline as a potent pde inhibitor for the management of schizophrenia
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (315 residues) CATH domain: 1.10.1300.10
3uuo
The discovery of potent, selectivity, and orally bioavailabl pyrozoloquinolines as pde10 inhibitors for the treatment of schizophrenia
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (305 residues) CATH domain: 1.10.1300.10
3v93
Unliganded structure of tcrpdec1 catalytic domain
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: pdec, trypanosoma cruzi. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H (329 residues) CATH domain: 1.10.1300.10
3v94
Tcrpdec1 catalytic domain in complex with inhibitor wyq16
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: trypanosoma cruzi. Gene: pdec, tcrpdec1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H (332 residues) CATH domain: 1.10.1300.10
3wi2
Crystal structure of pde10a in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
3ws8
Crystal structure of pde10a in complex with a benzimidazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
3ws9
Crystal structure of pde10a in complex with a benzimdazole i
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
4ael
Pde10a in complex with the inhibitor az5
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (320 residues) CATH domain: 1.10.1300.10
4ajd
Identification and structural characterization of pde10 fragment inhibitors
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (324 residues) CATH domain: 1.10.1300.10
4ajf
Identification and structural characterization of pde10 fragment inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (328 residues) CATH domain: 1.10.1300.10
4ajg
Identification and structural characterization of pde10 fragment inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (321 residues) CATH domain: 1.10.1300.10
4ajm
Development of a plate-based optical biosensor methodology to identify pde10 fragment inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (320 residues) CATH domain: 1.10.1300.10
4bbx
Discovery of a potent, selective and orally active pde10a inhibitor for the treatment of schizophrenia
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: brain. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (312 residues) CATH domain: 1.10.1300.10
4ddl
Pde10a crystal structure complexed with novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
4dff
The sar development of dihydroimidazoisoquinoline derivative phosphodiesterase 10a inhibitors for the treatment of schiz
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (307 residues) CATH domain: 1.10.1300.10
4fcb
Potent and selective phosphodiesterase 10a inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
4fcd
Potent and selective phosphodiesterase 10a inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
4heu
Crystal structure of pde10a with a biaryl ether inhibitor (( ((1h-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piper yl)methanol)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
4hf4
Crystal structure of pde10a with a biaryl ether inhibitor (1 (benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4 ethanol)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
4htx
Crystal structure of pde2 catalytic domain in complex with b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde2a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (338 residues) CATH domain: 1.10.1300.10
4htz
Crystal structure of pde2 catalytic domain in space group p1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde2a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (338 residues) CATH domain: 1.10.1300.10
4jib
Crystal structure of of pde2-inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (340 residues) CATH domain: 1.10.1300.10
4lkq
Crystal structure of pde10a2 with fragment zt017
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4llj
Crystal structure of pde10a2 with fragment zt214
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (329 residues) CATH domain: 1.10.1300.10
4llk
Crystal structure of pde10a2 with fragment zt217
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4llp
Crystal structure of pde10a2 with fragment zt401
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4llx
Crystal structure of pde10a2 with fragment zt434
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4lm0
Crystal structure of pde10a2 with fragment zt448
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4lm1
Crystal structure of pde10a2 with fragment zt450
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (332 residues) CATH domain: 1.10.1300.10
4lm2
Crystal structure of pde10a2 with fragment zt462
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 8ZE is 47.06% similar to enzyme reactant Nucleoside
4lm3
Crystal structure of pde10a2 with fragment zt464
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (331 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 9ZE is 42.11% similar to enzyme product nucleoside
4lm4
Crystal structure of pde10a2 with fragment zt902
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4mrw
Crystal structure of pde10a2 with fragment zt0120 (7-chloroq ol)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4mrz
Crystal structure of pde10a2 with fragment zt0429 (4-methyl- nitropyridin-2-amine)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4ms0
Crystal structure of pde10a2 with fragment zt0443 (6-chlorop 2,4-diamine)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4msa
Crystal structure of pde10a2 with fragment zt0449 (5-nitro-1 benzimidazole)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4msc
Crystal structure of pde10a2 with fragment zt1595 (2-[(quino yloxy)methyl]quinoline)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
4mse
Crystal structure of pde10a2 with fragment zt1597 (2-({[(2s) 2,3-dihydro-1,3-benzothiazol-5-yl]oxy}methyl)quinoline)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4msh
Crystal structure of pde10a2 with fragment zt0143 ((2s)-4-ch dihydro-1,3-benzothiazol-2-amine)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
4msn
Crystal structure of pde10a2 with fragment zt0451 (8-nitroqu
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4muw
Crystal structure of pde10a with novel keto-benzimidazole in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group GOL is 46.15% similar to enzyme reactant Nucleoside
4mvh
Crystal structure of pde10a with novel keto-benzimidazole in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (307 residues) CATH domain: 1.10.1300.10