PDBsum entry 4zko

Hydrolase/hydrolase inhibitor

PDB id: 4zko

Contents

Protein chain

247 a.a.

Ligands

ALA-ARG

GLY-LEU

SO4

P6G

Waters ×213

PDB id:

4zko

Name:

Hydrolase/hydrolase inhibitor

Title:

The crystal structure of upain-1-w3a in complex with upa at ph7.4

Structure:

Urokinase-type plasminogen activator. Chain: u. Fragment: unp residues 179-425. Synonym: upa. Engineered: yes. Mutation: yes. N-terminal fragment of upain-1-w3a. Chain: p. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.

Resolution:

1.29Å R-factor: 0.211 R-free: 0.225

Authors:

L.Jiang,P.A.Andreasen,M.Huang

Key ref:

L.Jiang et al. The crystal structure of mupain-1-Ig in complex with murinised human upa at ph7.4. To be published, .

Date:

30-Apr-15 Release date: 18-May-16

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 247 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.