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PDBsum entry 4xsk
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Blood clotting
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PDB id
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4xsk
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PDB id:
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| Name: |
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Blood clotting
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Title:
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Structure of paitrap, an upa mutant
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Structure:
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Urokinase-type plasminogen activator. Chain: u. Fragment: unp residues 162-407. Synonym: upa. Engineered: yes. Mutation: yes. Other_details: iiggefttienqpwfaaiyrrhrrgsvtyvcggslispcwvisathcfidypkkedyivylgrsrlnsn tqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqtialpsmyndpqfgtsceit
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris gs115. Expression_system_taxid: 644223
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Resolution:
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1.50Å
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R-factor:
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0.176
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R-free:
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0.209
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Authors:
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L.Gong,V.Proulle,Z.Hong,Z.Lin,M.Liu,C.Yuan,L.Lin,B.Furie, R.Flaumenhaft,P.Andreasen,B.Furie,M.Huang
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Key ref:
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L.Gong
et al.
Structure of paitrap, An upa mutant.
To be published,
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Date:
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22-Jan-15
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Release date:
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03-Feb-16
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PROCHECK
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Headers
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References
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P00749
(UROK_HUMAN) -
Urokinase-type plasminogen activator from Homo sapiens
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Seq:
Struc:
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431 a.a.
246 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 5 residue positions (black
crosses)
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Enzyme class:
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E.C.3.4.21.73
- u-plasminogen activator.
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Reaction:
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Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
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Links
