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PDBsum entry 4pv7
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Hydrolase/hydrolase inhibitor
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PDB id
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4pv7
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor
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Structure:
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Dipeptidyl peptidase 4 soluble form. Chain: a, b. Synonym: adabp, adenosine deaminase complexing protein 2, adcp-2, dipeptidyl peptidase iv, dpp iv, t-cell activation antigen cd26, tp103, dipeptidyl peptidase iv soluble form. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: adcp2, cd26, dpp4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Resolution:
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3.24Å
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R-factor:
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0.225
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R-free:
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0.264
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Authors:
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P.Xiao,R.Guo,S.Huang,H.Cui,S.Ye,Z.Zhang
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Key ref:
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P.Xiao
et al.
(2014).
Discovery of dipeptidyl peptidase IV (dpp4) inhibitor on a novel indole scaffold.
Chin chem lett,
25,
673.
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Date:
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15-Mar-14
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Release date:
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18-Mar-15
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PROCHECK
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Headers
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References
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P27487
(DPP4_HUMAN) -
Dipeptidyl peptidase 4 from Homo sapiens
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Seq:
Struc:
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766 a.a.
727 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.14.5
- dipeptidyl-peptidase Iv.
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Reaction:
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Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc, from a polypeptide, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
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Links
