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PDBsum entry 4gud
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PDB id:
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Transferase
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Title:
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Crystal structure of amidotransferase hish from vibrio cholerae
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Structure:
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Imidazole glycerol phosphate synthase subunit hish. Chain: a, b. Synonym: igp synthase glutamine amidotransferase subunit, igp synthase subunit hish, imgp synthase subunit hish, igps subunit hish. Engineered: yes
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Source:
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Vibrio cholerae. Organism_taxid: 243277. Strain: o1 biovar el tor str. N16961. Gene: hish, vc_1136. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Resolution:
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1.91Å
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R-factor:
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0.176
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R-free:
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0.208
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Authors:
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N.Maltseva,Y.Kim,S.Shatsman,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)
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Key ref:
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N.Maltseva
et al.
Crystal structure of amidotransferase hish from vibri cholerae..
To be published,
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Date:
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29-Aug-12
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Release date:
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12-Sep-12
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PROCHECK
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Headers
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References
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Q9KSX0
(HIS5_VIBCH) -
Imidazole glycerol phosphate synthase subunit HisH from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
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Seq:
Struc:
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203 a.a.
197 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 2:
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E.C.3.5.1.2
- glutaminase.
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Reaction:
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L-glutamine + H2O = L-glutamate + NH4+
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L-glutamine
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+
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H2O
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=
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L-glutamate
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+
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NH4(+)
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Enzyme class 3:
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E.C.4.3.2.10
- imidazole glycerol-phosphate synthase.
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Reaction:
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5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta- D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol- 4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide + L-glutamate + H+
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5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta- D-ribosyl)imidazole-4-carboxamide
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+
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L-glutamine
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=
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D-erythro-1-(imidazol- 4-yl)glycerol 3-phosphate
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+
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5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide
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+
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L-glutamate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
