_EC 3.5.1.2 Glutaminase. 31 PDB entries  
EC 3.-.-.- Hydrolases. [20,909 PDB entries]
EC 3.5.-.- Acting on carbon-nitrogen bonds, other than peptide bonds. [1,657 PDB entries]
EC 3.5.1.- In linear amides. [603 PDB entries]
EC 3.5.1.2 Glutaminase. [31 PDB entries]    
1mki

Reaction: L-glutamine + H(2)O = L-glutamate + NH(3).
 


L-glutamine
+ H(2)O
=
L-glutamate
+ NH(3)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-glutamine amidohydrolase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 31 PDB entries in enzyme class E.C.3.5.1.2

  PDB code Protein
1mki
Crystal structure of bacillus subtilis probable glutaminase, apc1040
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: ybgj. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (312 residues) CATH domains: 3.40.710.10 1.10.1500.10
1u60
Mcsg apc5046 probable glutaminase ybas
Source: Escherichia coli. Organism_taxid: 562. Gene: ybas. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (309 residues) CATH domain: 3.40.710.10
2dfw
Crystal structure of a major fragment of the salt-tolerant glutaminase from micrococcus luteus k-3
Source: Micrococcus luteus. Organism_taxid: 1270. Strain: k-3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (393 residues) CATH domain: 3.40.710.10
2osu
Probable glutaminase from bacillus subtilis complexed with 6-diazo-5-oxo-l-norleucine
Source: Bacillus subtilis. Organism_taxid: 1423. Strain: 168. Gene: glsa1, glsa, bsu02430. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (306 residues) CATH domains: 3.40.710.10 1.10.1500.10
Bound ligand:   Het Group DON is 69.00% similar to enzyme reactant L-glutamine
2pby
Probable glutaminase from geobacillus kaustophilus hta426
Source: Geobacillus kaustophilus. Organism_taxid: 235909. Strain: hta426. Gene: gk2125. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (291 residues) CATH domains: 3.40.710.10 1.10.1500.10
3agd
Crystal structure of mglu in its native form in the presence nacl
Source: Micrococcus luteus. Organism_taxid: 1270. Strain: k-3. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (440 residues) CATH domain: 3.40.710.10
3age
Crystal structure of mglu in its l-glutamate binding form in presence of 4.3m nacl
Source: Micrococcus luteus. Organism_taxid: 1270. Strain: k-3. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (447 residues) CATH domain: 3.40.710.10
Bound ligand:   Het Group GLU corresponds to enzyme product L-glutamate
3agf
Crystal structure of bacillus glutaminase in the presence of
Source: Bacillus subtilis. Organism_taxid: 1423. Strain: 168. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (299 residues) CATH domains: 3.40.710.10 1.10.1500.10
3brm
Crystal structure of the covalent complex between the bacillus subtilis glutaminase ybgj and 5-oxo-l-norleucine formed by reaction of the protein with 6-diazo-5-oxo-l- norleucine
Source: Bacillus subtilis. Strain: 168. Gene: glsa1, glsa, ybgj, bsu02430. Expressed in: escherichia coli.
Chains: A, B (290 residues) CATH domains: 3.40.710.10 1.10.1500.10
Bound ligand:   Het Group ONL is 81.00% similar to enzyme reactant L-glutamine
3czd
Crystal structure of human glutaminase in complex with l-glu
Source: Homo sapiens. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.710.10
Bound ligand:   Het Group GLU corresponds to enzyme product L-glutamate
3d54
Stucture of purlqs from thermotoga maritima
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: purl. Expressed in: escherichia coli. Gene: purq. Expressed in: escherichia coli
Chains: D, H, L (212 residues) CATH domain: 3.40.50.880
3if5
Crystal structure analysis of mglu
Source: Micrococcus luteus. Micrococcus lysodeikticus. Organism_taxid: 1270. Strain: k-3. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (398 residues) CATH domain: 3.40.710.10
3ih8
Crystal structure analysis of mglu in its native form
Source: Micrococcus luteus. Micrococcus lysodeikticus. Organism_taxid: 1270. Strain: k-3. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (415 residues) CATH domain: 3.40.710.10
3ih9
Crystal structure analysis of mglu in its tris form
Source: Micrococcus luteus. Micrococcus lysodeikticus. Organism_taxid: 1270. Strain: k-3. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (448 residues) CATH domain: 3.40.710.10
3iha
Crystal structure analysis of mglu in its glutamate form
Source: Micrococcus luteus. Micrococcus lysodeikticus. Organism_taxid: 1270. Strain: k-3. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (435 residues) CATH domain: 3.40.710.10
3ihb
Crystal structure analysis of mglu in its tris and glutamate form
Source: Micrococcus luteus. Micrococcus lysodeikticus. Organism_taxid: 1270. Strain: k-3. Gene: glutaminase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (450 residues) CATH domain: 3.40.710.10
3ss3
Crystal structure of mouse glutaminasE C, ligand-free form
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: gls, gls1, mkiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (394 residues) CATH domains: Unassigned 3.40.710.10
3ss4
Crystal structure of mouse glutaminasE C, phosphate-bound fo
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: gls, gls1, mkiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (390 residues) CATH domains: Unassigned 3.40.710.10
3ss5
Crystal structure of mouse glutaminasE C, l-glutamate-bound
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: gls, gls1, mkiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (394 residues) CATH domains: Unassigned 3.40.710.10
Bound ligand:   Het Group GLU corresponds to enzyme product L-glutamate
3unw
Crystal structure of human gac in complex with glutamate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838
Chains: A, B, C, D (407 residues) CATH domains: Unassigned 3.40.710.10
Bound ligand:   Het Group GLU corresponds to enzyme product L-glutamate
3uo9
Crystal structure of human gac in complex with glutamate and
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (411 residues) CATH domains: Unassigned 3.40.710.10
3voy
Crystal structure of human glutaminase in apo form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (315 residues) CATH domain: 3.40.710.10
3voz
Crystal structure of human glutaminase in complex with bptes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (313 residues) CATH domain: 3.40.710.10
3vp0
Crystal structure of human glutaminase in complex with l-glu
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (310 residues) CATH domain: 3.40.710.10
Bound ligand:   Het Group GLN corresponds to enzyme reactant L-glutamine
3vp1
Crystal structure of human glutaminase in complex with l-glu bptes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (313 residues) CATH domain: 3.40.710.10
Bound ligand:   Het Group GLU corresponds to enzyme product L-glutamate
3vp2
Crystal structure of human glutaminase in complex with inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (311 residues) CATH domain: 3.40.710.10
3vp3
Crystal structure of human glutaminase in complex with inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (311 residues) CATH domain: 3.40.710.10
3vp4
Crystal structure of human glutaminase in complex with inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (312 residues) CATH domain: 3.40.710.10
4bqm
Crystal structure of human liver-type glutaminase, catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
Chains: A, B (296 residues) CATH domain: 3.40.710.10
4jkt
Crystal structure of mouse glutaminasE C, bptes-bound form
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (395 residues) CATH domains: Unassigned 3.40.710.10
4o7d
Crystal structure of human glutaminase in complex don
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gls, gls1, kiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (313 residues) CATH domain: 3.40.710.10
Bound ligand:   Het Group ONL is 81.82% similar to enzyme reactant L-glutamine