PDBsum entry 4bpv

Hydrolase

PDB id: 4bpv

Contents

Protein chains

219 a.a.

89 a.a.

Ligands

OFH ×5

Waters ×938

PDB id:

4bpv

Name:

Hydrolase

Title:

Mouse cathepsin s with covalent ligand

Structure:

Cathepsin s. Chain: a, b, c, d, e, k. Fragment: residues 116-340. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å R-factor: 0.214 R-free: 0.255

Authors:

D.W.Banner,J.Benz,B.Gsell,M.Stihle,A.Ruf,W.Haap

Key ref:

W.Haap and d.w.banner Cathepsin s nitrile inhibitors. To be published, .

Date:

28-May-13 Release date: 11-Jun-14

Protein chains

O70370  (CATS_MOUSE) -  Cathepsin S from Mus musculus

Seq: 340 a.a.

Struc: 219 a.a.*

Protein chain

O70370  (CATS_MOUSE) -  Cathepsin S from Mus musculus

Seq: 340 a.a.

Struc: 89 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E, K: E.C.3.4.22.27 - cathepsin S.
• Reaction: Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.