EC - Cathepsin S

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IntEnz Enzyme Nomenclature


Accepted name:
cathepsin S
Systematic name:



A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004218
CAS Registry Number: 71965-46-3


  1. Turnšek, T., Kregar, I. and Lebez, D.
    Acid sulphydryl protease from calf lymph nodes.
    Biochim. Biophys. Acta 403: 514-520 (1975). [PMID: 1182153]
  2. Brömme, D., Steinert, A., Friebe, S., Fittkau, S., Wiederanders, B. and Kirschke, H.
    The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B.
    Biochem. J. 264: 475-485 (1989). [PMID: 2604727]
  3. Kirschke, H., Wiederanders, B., Brömme, D. and Rinne, A.
    Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.
    Biochem. J. 264: 467-473 (1989). [PMID: 2690828]

[EC created 1992]