PDBsum entry 3vi4

Cell adhesion/immune system

PDB id: 3vi4

Contents

Protein chains

601 a.a.

431 a.a.

219 a.a.

218 a.a.

Ligands

ARG-GLY-ASP-ASN

ARG-GLY-ASP

NAG-NAG ×2

NAG-NAG-BMA-MAN-MAN-MAN ×2

NAG ×11

Metals

_CA ×10

_MG ×2

PDB id:

3vi4

Name:

Cell adhesion/immune system

Title:

Crystal structure of alpha5beta1 integrin headpiece in complex with rgd peptide

Structure:

Integrin alpha-5. Chain: a, c. Synonym: cd49 antigen-like family member e, fibronectin receptor subunit alpha, integrin alpha-f, vla-5, integrin alpha-5 heavy chain, integrin alpha-5 light chain. Engineered: yes. Integrin beta-1. Chain: b, d. Synonym: fibronectin receptor subunit beta, vla-4 subunit beta.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fnra, itga5. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: cho-lec3.2.8.1 cell. Gene: fnrb, itgb1, mdf2, msk12. Mus musculus.

Resolution:

2.90Å R-factor: 0.218 R-free: 0.275

Authors:

M.Nagae,T.Nogi,J.Takagi

Key ref:

M.Nagae et al. (2012). Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol, 197, 131-140. PubMed id: 22451694

Date:

21-Sep-11 Release date: 22-Feb-12

Protein chains

P08648  (ITA5_HUMAN) -  Integrin alpha-5 from Homo sapiens

Seq: 1049 a.a.

Struc: 601 a.a.

Protein chains

P05556  (ITB1_HUMAN) -  Integrin beta-1 from Homo sapiens

Seq: 798 a.a.

Struc: 431 a.a.*

Protein chains

No UniProt id for this chain

Struc: 219 a.a.

Protein chains

No UniProt id for this chain

Struc: 218 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

J Cell Biol 197:131-140 (2012)

PubMed id: 22451694

Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor.

M.Nagae, S.Re, E.Mihara, T.Nogi, Y.Sugita, J.Takagi.

ABSTRACT

No abstract given.