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UniProt functional annotation for P08648 | ||
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| UniProt code: P08648. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}. |
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| Function: | |
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:12907437}. |
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| Function: | |
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:24478423}. |
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| Function: | |
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
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| Subunit: | |
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with CCN3. ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430). ITGA5:ITGB1 interacts with ACE2 (PubMed:33102950). {ECO:0000269|PubMed:11912194, ECO:0000269|PubMed:12695522, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:16051604, ECO:0000269|PubMed:16754960, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:24011356, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:33102950}. |
| Subunit: | |
(Microbial infection) Integrin ITGA5:ITGB1 interacts with human metapneumovirus fusion protein. {ECO:0000269|PubMed:12907437}. |
| Subunit: | |
(Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid proteins. {ECO:0000269|PubMed:24478423}. |
| Subunit: | |
(Microbial infection) Interacts with HIV-1 Tat. {ECO:0000269|PubMed:10397733}. |
| Subunit: | |
(Microbial infection) ITGA5:ITGB1 interacts with SARS coronavirus-2/SARS-CoV-2 spike protein. {ECO:0000269|PubMed:33102950}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}. Cell surface {ECO:0000269|PubMed:17158881}. |
| Ptm: | |
Proteolytic cleavage by PCSK5 mediates activation of the precursor. {ECO:0000269|PubMed:22740495}. |
| Similarity: | |
Belongs to the integrin alpha chain family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.