PDBsum entry 3tdb

Isomerase/inhibitor

PDB id: 3tdb

Contents

Protein chain

146 a.a.

Ligands

3TB

PE4

Waters ×64

PDB id:

3tdb

Name:

Isomerase/inhibitor

Title:

Human pin1 bound to trans peptidomimetic inhibitor

Structure:

Peptidyl-prolyl cis-trans isomerase nima-interacting 1. Chain: a. Fragment: unp residues 6-163. Synonym: peptidyl-prolyl cis-trans isomerase pin1, ppiase pin1, rotamase pin1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pin1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.27Å R-factor: 0.221 R-free: 0.256

Authors:

M.Zhang,Y.Zhang

Key ref:

M.Zhang et al. (2012). Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. Acs Chem Biol, 7, 1462-1470. PubMed id: 22670809 DOI: 10.1021/cb3000887

Date:

10-Aug-11 Release date: 27-Jun-12

Protein chain

Q13526  (PIN1_HUMAN) -  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 from Homo sapiens

Seq: 163 a.a.

Struc: 146 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1021/cb3000887

Acs Chem Biol 7:1462-1470 (2012)

PubMed id: 22670809

Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code.

M.Zhang, X.J.Wang, X.Chen, M.E.Bowman, Y.Luo, J.P.Noel, A.D.Ellington, F.A.Etzkorn, Y.Zhang.

ABSTRACT

No abstract given.