PDBsum entry 3qlf

Transferase

PDB id: 3qlf

Contents

Protein chains

249 a.a.

Ligands

PD5 ×2

Waters ×110

PDB id:

3qlf

Name:

Transferase

Title:

Crystal structure of the l317i mutant of thE C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a, b. Synonym: proto-oncogenE C-src, pp60c-src, p60-src. Engineered: yes. Mutation: yes

Source:

Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.75Å R-factor: 0.194 R-free: 0.232

Authors:

R.Boubeva,L.Pernot,R.Perozzo,L.Scapozza

Key ref:

R.Boubeva et al. A single amino-Acid dictates the dynamics of the swit between active and inactive c-Src conformation. To be published, .

Date:

02-Feb-11 Release date: 08-Feb-12

Protein chains

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 249 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site