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PDBsum entry 3qlf
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References listed in PDB file
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Key reference
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Title
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A single amino-Acid dictates the dynamics of the swit between active and inactive c-Src conformation
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Authors
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R.Boubeva,
L.Pernot,
A.Cristiani,
L.Moretti,
A.Berteotti,
R.Perozzo,
F.Gervasio,
L.Scapozza.
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Ref.
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TO BE PUBLISHED ...
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Secondary reference #1
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Title
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C-Src binds to the cancer drug imatinib with an inactive abl/c-Kit conformation and a distributed thermodynamic penalty.
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Authors
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M.A.Seeliger,
B.Nagar,
F.Frank,
X.Cao,
M.N.Henderson,
J.Kuriyan.
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Ref.
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Structure, 2007,
15,
299-311.
[DOI no: ]
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PubMed id
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Figure 1.
Figure 1. The Imatinib-Binding Pocket
(A) Chemical
structure of imatinib.
(B) The imatinib-binding pocket in
Abl (PDB code 1OPJ) (Nagar et al., 2003). The Cα atoms of
residues that interact with imatinib are depicted as spheres.
Blue, residues that are invariant among Abl, c-Src, Lck, Hck,
PDGFR, and c-Kit; yellow, residues that are identical between
Abl and c-Src, but not between Abl and c-Kit or PDGFR; red,
residues unique to Abl.
(C) Sequence alignment of Abl,
c-Src, Hck, Lck, PDGFR, and c-Kit kinase domains. Residues that
are the same as in Abl are yellow. Residues that interact with
imatinib in the structure of Abl are in orange. Stars are color
coded according to the spheres in (B).
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Figure 7.
Figure 7. Comparison of Imatinib-Bound Structures
(A)
Structure of c-Src•imatinib (this work, PDB code 2OIQ). The
activation loop is disordered from residue 408 to residue 420,
and the phosphate-binding P loop is extended, leaving the
phenylalanine side chain solvent exposed.
(B) Structure of
Abl•imatinib (PDB code 1OPJ [Nagar et al., 2002]). The
phosphate-binding loop is kinked toward the C lobe of the
kinase, allowing for hydrogen bonds between Tyr253 and Asn322
(not shown).
(C) Structure of c-Kit•imatinib (PDB code
1T46 [Mol et al., 2004]). The phosphate-binding loop is
extended, as seen in the structure of c-Src, and Phe600 is
solvent exposed.
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The above figures are
reproduced from the cited reference
with permission from Cell Press
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Secondary reference #2
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Title
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Small molecule recognition of c-Src via the imatinib-Binding conformation.
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Authors
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A.C.Dar,
M.S.Lopez,
K.M.Shokat.
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Ref.
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Chem Biol, 2008,
15,
1015-1022.
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PubMed id
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