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PDBsum entry 3pmw
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Transport protein
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PDB id
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3pmw
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References listed in PDB file
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Key reference
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Title
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Structure based evolution of a novel series of positive modulators of the ampa receptor.
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Authors
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C.Jamieson,
J.K.Maclean,
C.I.Brown,
R.A.Campbell,
K.J.Gillen,
J.Gillespie,
B.Kazemier,
M.Kiczun,
Y.Lamont,
A.J.Lyons,
E.M.Moir,
J.A.Morrow,
J.Pantling,
Z.Rankovic,
L.Smith.
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Ref.
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Bioorg Med Chem Lett, 2011,
21,
805-811.
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PubMed id
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Abstract
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Starting from compound 1, we utilized biostructural data to successfully evolve
an existing series into a new chemotype with a promising overall profile,
exemplified by 19.
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