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PDBsum entry 3mv8
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Immune system
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PDB id
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3mv8
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Contents |
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276 a.a.
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100 a.a.
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11 a.a.
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200 a.a.
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242 a.a.
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References listed in PDB file
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Key reference
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Title
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Allelic polymorphism in the t cell receptor and its impact on immune responses.
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Authors
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S.Gras,
Z.Chen,
J.J.Miles,
Y.C.Liu,
M.J.Bell,
L.C.Sullivan,
L.Kjer-Nielsen,
R.M.Brennan,
J.M.Burrows,
M.A.Neller,
R.Khanna,
A.W.Purcell,
A.G.Brooks,
J.Mccluskey,
J.Rossjohn,
S.R.Burrows.
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Ref.
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J Exp Med, 2010,
207,
1555-1567.
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PubMed id
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Abstract
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In comparison to human leukocyte antigen (HLA) polymorphism, the impact of
allelic sequence variation within T cell receptor (TCR) loci is much less
understood. Particular TCR loci have been associated with autoimmunity, but the
molecular basis for this phenomenon is undefined. We examined the T cell
response to an HLA-B*3501-restricted epitope (HPVGEADYFEY) from Epstein-Barr
virus (EBV), which is frequently dominated by a TRBV9*01(+) public TCR (TK3).
However, the common allelic variant TRBV9*02, which differs by a single amino
acid near the CDR2beta loop (Gln55-->His55), was never used in this response.
The structure of the TK3 TCR, its allelic variant, and a nonnaturally occurring
mutant (Gln55-->Ala55) in complex with HLA-B*3501(HPVGEADYFEY) revealed that
the Gln55-->His55 polymorphism affected the charge complementarity at the
TCR-peptide-MHC interface, resulting in reduced functional recognition of the
cognate and naturally occurring variants of this EBV peptide. Thus, polymorphism
in the TCR loci may contribute toward variability in immune responses and the
outcome of infection.
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