PDBsum entry 3mj6

Immune system

PDB id

3mj6

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Contents

			Protein chain

					227 a.a. *

			Ligands

					NAG-FUC


					NAG ×2


					FMT ×8

			Metals

					_NA

			Waters ×129

* Residue conservation analysis

PDB id:

3mj6

Links

Name:

Immune system

Title:

Crystal structure of the gammadelta t cell costimulatory receptor junctional adhesion molecule-like protein, jaml

Structure:

Junctional adhesion molecule-like. Chain: a. Fragment: extracellular domain (unp residues 21-280). Synonym: dendritic cell-specific protein crea7, mcrea7. Engineered: yes. Mutation: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: amica1, gm638, jaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.

Resolution:

2.19Å

R-factor:

0.172

R-free:

0.213

Authors:

P.Verdino,I.A.Wilson

Key ref:

P.Verdino et al. (2010). The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science, 329, 1210-1214. PubMed id: 20813955

Date:

12-Apr-10

Release date:

22-Sep-10

PROCHECK

	Headers

	References

Protein chain

Q80UL9 (JAML_MOUSE) - Junctional adhesion molecule-like from Mus musculus

Seq: Struc:					379 a.a. 227 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)

	Science 329:1210-1214 (2010)
PubMed id: 20813955

The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.
P.Verdino, D.A.Witherden, W.L.Havran, I.A.Wilson.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

21366418

D.Henaff, S.Salinas, and E.J.Kremer (2011).
An adenovirus traffic update: from receptor engagement to the nuclear pore.

Future Microbiol, 6, 179-192.

21220118

P.Verdino, D.A.Witherden, M.S.Ferguson, A.L.Corper, A.Schiefner, W.L.Havran, and I.A.Wilson (2011).
Molecular insights into γδ T cell costimulation by an anti-JAML antibody.

Structure, 19, 80-89.

PDB code:

3mj9

21511182

Y.Zhu, S.Yao, and L.Chen (2011).
Cell surface signaling molecules in the control of immune responses: a tide model.

Immunity, 34, 466-478.

20813941

A.S.Shaw, and Y.Huang (2010).
Immunology. CAR'ing for the skin.

Science, 329, 1154-1155.

20813954

D.A.Witherden, P.Verdino, S.E.Rieder, O.Garijo, R.E.Mills, L.Teyton, W.H.Fischer, I.A.Wilson, and W.L.Havran (2010).
The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation.

Science, 329, 1205-1210.

20879165

L.Bird (2010).
Infectious disease: The tuberculosis signature.

Nat Rev Immunol, 10, 677.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.