UniProt functional annotation for Q80UL9



	UniProt functional annotation for Q80UL9

UniProt code: Q80UL9.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:20813954}.

Subunit: Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. {ECO:0000269|PubMed:20813954, ECO:0000269|PubMed:20813955}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:20813954}; Single-pass type I membrane protein {ECO:0000269|PubMed:20813954}. Cell junction {ECO:0000250|UniProtKB:Q86YT9}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts. {ECO:0000250|UniProtKB:Q86YT9}.

Tissue specificity: Expressed by gamma-delta intraepithelial T cells (at protein level). {ECO:0000269|PubMed:20813954}.

Domain: The Ig-like V-type domain 1 mediates interaction with CXADR (PubMed:20813954). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:20813955). {ECO:0000269|PubMed:20813954, ECO:0000269|PubMed:20813955}.

Similarity: Belongs to the immunoglobulin superfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269\|PubMed:20813954}.


Subunit:		Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. {ECO:0000269\|PubMed:20813954, ECO:0000269\|PubMed:20813955}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:20813954}; Single-pass type I membrane protein {ECO:0000269\|PubMed:20813954}. Cell junction {ECO:0000250\|UniProtKB:Q86YT9}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts. {ECO:0000250\|UniProtKB:Q86YT9}.
Tissue specificity:		Expressed by gamma-delta intraepithelial T cells (at protein level). {ECO:0000269\|PubMed:20813954}.
Domain:		The Ig-like V-type domain 1 mediates interaction with CXADR (PubMed:20813954). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:20813955). {ECO:0000269\|PubMed:20813954, ECO:0000269\|PubMed:20813955}.
Similarity:		Belongs to the immunoglobulin superfamily. {ECO:0000305}.