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PDBsum entry 3iby
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Transport protein
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PDB id
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3iby
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References listed in PDB file
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Key reference
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Title
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Structure of the gtpase and gdi domains of feob, The ferrous iron transporter of legionella pneumophila.
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Authors
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N.Petermann,
G.Hansen,
C.L.Schmidt,
R.Hilgenfeld.
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Ref.
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Febs Lett, 2010,
584,
733-738.
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PubMed id
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Abstract
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Prokaryotic pathogens have developed specialized mechanisms for efficient uptake
of ferrous iron (Fe(2+)) from the host. In Legionella pneumophila, the causative
agent of Legionnaires' disease, the transmembrane GTPase FeoB plays a key role
in Fe(2+) acquisition and virulence. FeoB consists of a membrane-embedded core
and an N-terminal, cytosolic region (NFeoB). Here, we report the crystal
structure of NFeoB from L. pneumophila, revealing a monomeric protein comprising
two separate domains with GTPase and guanine-nucleotide dissociation inhibitor
(GDI) functions. The GDI domain displays a novel fold, whereas the overall
structure of the GTPase domain resembles that of known G domains but is in the
rarely observed nucleotide-free state.
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