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PDBsum entry 3cxc
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Contents |
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237 a.a.
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337 a.a.
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246 a.a.
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140 a.a.
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172 a.a.
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119 a.a.
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29 a.a.
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156 a.a.
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142 a.a.
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132 a.a.
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145 a.a.
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194 a.a.
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186 a.a.
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115 a.a.
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143 a.a.
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95 a.a.
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150 a.a.
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81 a.a.
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119 a.a.
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53 a.a.
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65 a.a.
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154 a.a.
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82 a.a.
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142 a.a.
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73 a.a.
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56 a.a.
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46 a.a.
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92 a.a.
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 _CL
×22
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 _NA
×86
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 _MG
×117
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 _CD
×5
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 __K
×2
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References listed in PDB file
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Key reference
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Title
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Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
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Authors
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J.Zhou,
A.Bhattacharjee,
S.Chen,
Y.Chen,
E.Duffy,
J.Farmer,
J.Goldberg,
R.Hanselmann,
J.A.Ippolito,
R.Lou,
A.Orbin,
A.Oyelere,
J.Salvino,
D.Springer,
J.Tran,
D.Wang,
Y.Wu,
G.Johnson.
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Ref.
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Bioorg Med Chem Lett, 2008,
18,
6175-6178.
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PubMed id
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Abstract
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We have developed a first generation of hybrid sparsomycin-linezolid compounds
into a new family of orally bioavailable biaryloxazolidinones that have activity
against both linezolid-susceptible and -resistant gram-positive bacteria as well
as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella
catarrahalis. The convergent synthesis of these new compounds is detailed.
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