PDBsum entry 3vjm

Hydrolase/hydrolase inhibitor

PDB id: 3vjm

Contents

Protein chain

729 a.a.

Ligands

NAG-NAG ×5

W61 ×2

NAG ×7

Waters ×987

PDB id:

3vjm

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of human depiptidyl peptidase iv (dpp-4) in complex with a prolylthiazolidine inhibitor #1

Structure:

Dipeptidyl peptidase 4. Chain: a, b. Fragment: unp residues 33-766. Synonym: adabp, adenosine deaminase complexing protein 2, adcp-2, dipeptidyl peptidase iv, dpp iv, t-cell activation antigen cd26, tp103, dipeptidyl peptidase 4 membrane form, dipeptidyl peptidase iv membrane form, dipeptidyl peptidase 4 soluble form, dipeptidyl peptidase iv soluble form. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp4, adcp2, cd26. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: expressf+.

Resolution:

2.10Å R-factor: 0.187 R-free: 0.224

Authors:

F.Akahoshi,H.Kishida,I.Miyaguchi,T.Yoshida,S.Ishii

Key ref:

T.Yoshida et al. (2012). Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group. Bioorg Med Chem Lett, 20, 5033-5041. PubMed id: 22824762

Date:

24-Oct-11 Release date: 15-Aug-12

Protein chains

P27487  (DPP4_HUMAN) -  Dipeptidyl peptidase 4 from Homo sapiens

Seq: 766 a.a.

Struc: 729 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.14.5 - dipeptidyl-peptidase Iv.
• Reaction: Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc, from a polypeptide, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.

Bioorg Med Chem Lett 20:5033-5041 (2012)

PubMed id: 22824762

Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group.

T.Yoshida, F.Akahoshi, H.Sakashita, S.Sonda, M.Takeuchi, Y.Tanaka, M.Nabeno, H.Kishida, I.Miyaguchi, Y.Hayashi.

ABSTRACT

No abstract given.