PDBsum entry 3sos

Hydrolase/hydrolase inhibitor

PDB id: 3sos

Contents

Protein chain

236 a.a.

Ligands

CIT

TRS

O61

Waters ×82

PDB id:

3sos

Name:

Hydrolase/hydrolase inhibitor

Title:

Benzothiazinone inhibitor in complex with fxia

Structure:

Coagulation factor xi. Chain: a. Synonym: fxi, plasma thromboplastin antecedent, pta, coagulation factor xia heavy chain, coagulation factor xia light chain. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922

Resolution:

2.58Å R-factor: 0.203 R-free: 0.278

Authors:

X.Fradera,B.Kazemier,A.Oubrie

Key ref:

X.Fradera et al. (2012). High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors. Acta Crystallogr Sect F Struct Biol Cryst Commun, 68, 404-408. PubMed id: 22505407 DOI: 10.1107/S1744309112009037

Date:

30-Jun-11 Release date: 11-Apr-12

Protein chain

P03951  (FA11_HUMAN) -  Coagulation factor XI from Homo sapiens

Seq: 625 a.a.

Struc: 236 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.21.27 - coagulation factor XIa.
• Reaction: Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

DOI no: 10.1107/S1744309112009037

Acta Crystallogr Sect F Struct Biol Cryst Commun 68:404-408 (2012)

PubMed id: 22505407

High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.

X.Fradera, B.Kazemier, E.Carswell, A.Cooke, A.Oubrie, W.Hamilton, M.Dempster, S.Krapp, S.Nagel, A.Jestel.

ABSTRACT

No abstract given.