PDBsum entry 3nda

Hydrolase inhibitor

PDB id: 3nda

Contents

Protein chains

374 a.a. *

Ligands

1PE

Waters ×875

* Residue conservation analysis

PDB id:

3nda

Name:

Hydrolase inhibitor

Title:

Crystal structure of serpin from tick ixodes ricinus

Structure:

Serpin-2. Chain: a, b. Engineered: yes

Source:

Ixodes ricinus. Sheep tick. Organism_taxid: 34613. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.80Å R-factor: 0.173 R-free: 0.212

Authors:

P.Rezacova,Z.Kovarova,J.Chmelar,M.Mares

Key ref:

J.Chmelar et al. (2011). A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood, 117, 736-744. PubMed id: 20940421

Date:

07-Jun-10 Release date: 27-Oct-10

Protein chains

Q06B74  (Q06B74_IXORI) -  Serpin-2 from Ixodes ricinus

Seq: 397 a.a.

Struc: 374 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Blood 117:736-744 (2011)

PubMed id: 20940421

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.

J.Chmelar, C.J.Oliveira, P.Rezacova, I.M.Francischetti, Z.Kovarova, G.Pejler, P.Kopacek, J.M.Ribeiro, M.Mares, J.Kopecky, M.Kotsyfakis.

ABSTRACT

No abstract given.