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PDBsum entry 3khv
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Crystal structures of urokinase-type plasminogen activator in complex with 4-(aminomethyl) benzoic acid and 4-(aminomethyl-phenyl)-methanol
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Structure:
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Urokinase-type plasminogen activator. Chain: a. Fragment: c-terminal domain, unp residues 179-431. Synonym: u-plasminogen activator, upa, urokinase-type plasminogen activator chain b. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Resolution:
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2.35Å
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R-factor:
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0.228
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R-free:
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0.293
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Authors:
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L.-G.Jiang,G.-X.Zhao,X.-B.Bian,C.Yuan,Z.-X.Huang,M.-D.Huang
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Key ref:
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L.-G.Jiang
et al.
(2009).
Crystal structures of urokinase-Type plasminogen activator in complex with 4-(Aminomethyl) benzoic acid and 4-(Aminomethyl-Phenyl)-Methanol.
Chin j struct chem,
28,
253.
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Date:
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30-Oct-09
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Release date:
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01-Dec-09
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PROCHECK
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Headers
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References
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P00749
(UROK_HUMAN) -
Urokinase-type plasminogen activator from Homo sapiens
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Seq:
Struc:
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431 a.a.
239 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.4.21.73
- u-plasminogen activator.
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Reaction:
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Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
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Links
